ArticleHead & neck oncology2012
Structural validation of oral mucosal tissue using optical coherence tomography.
Article in Head & neck oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Identification and quantification of oral lymphatic vessel networks using optical coherence tomography (OCT).Biomedical optics express · 2026Article
- Volumetric Imaging of Ex Vivo Oral Mucosa Specimens with Multi-Scale Wide Field-of-View Optical Coherence Tomography/Microscopy in Near-Infrared-II Window.Diagnostics (Basel, Switzerland) · 2026Article
- Optical Coherence Tomography Assessment of Tongue Papillary Atrophy and Patient-Reported Impact on Taste Following Head and Neck Cancer Therapy.Journal of clinical medicine · 2026Article
- Role of optical imaging in oral cancer and oral potentially malignant disorders: implications for oral submucous fibrosis.Frontiers in oral health · 2025Review
- Application of Targeted Optical Coherence Tomography in Oral Cancer: A Cross-Sectional Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery.Diagnostics (Basel, Switzerland) · 2023Article
- Site-Coded Oral Squamous Cell Carcinoma Evaluation by Optical Coherence Tomography (OCT): A Descriptive Pilot Study.Cancers · 2022Article
- Article
- Convolutional dictionary learning for blind deconvolution of optical coherence tomography images.Biomedical optics express · 2022Article
- Application of optical coherence tomography to study the structural features of oral mucosa in biopsy tissues of oral dysplasia and carcinomas.Clinical oral investigations · 2021Article
- Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples.Journal of biomedical optics · 2020Article
- Role of modern imaging techniques for theExperimental and therapeutic medicine · 2019Review
- Wide-field in vivo oral OCT imaging.Biomedical optics express · 2015Article
- Surgical margins and its evaluation in oral cancer: a review.Journal of clinical and diagnostic research : JCDR · 2014Review
- Advances in optical adjunctive AIDS for visualisation and detection of oral malignant and potentially malignant lesions.International journal of dentistry · 2013Review
- In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology.Dermatology research and practice · 2013Article
- Carcinoma of the lip five years after bone marrow transplantation.Annali di stomatologiaArticle
Corrections and comments
- Expression of concern
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution.
objectivesThe overall aims of this study was to generate a bank of normative and pathological OCT data of the oral tissues to allow identification of cellular structures of normal and pathological processes with the aim to create a diagnostic algorithm which can be used in the early detection of oral disorders. MATERIAL AND
methodsSeventy-three patients with 78 suspicious oral lesions were referred for further management to the UCLH Head and Neck Centre, London. The entire cohort had their lesions surgically biopsied (incisional or excisional). The immediate ex vivo phase involved scanning the specimens using optical coherence tomography. The specimens were then processed by a histopathologist. Five tissue structures were evaluated as part of this study, including: keratin cell layer, epithelial layer, basement membrane, lamina propria and other microanatomical structures. Two independent assessors (clinician and pathologist trained to use OCT) assessed the OCT images and were asked to comment on the cellular structures and changes involving the five tissue structures in non-blind fashion.
resultsCorrect identification of the keratin cell layer and its structural changes was achieved in 87% of the cohort; for the epithelial layer it reached 93.5%, and 94% for the basement membrane. Microanatomical structures identification was 64% for blood vessels, 58% for salivary gland ducts and 89% for rete pegs. The agreement was "good" between the clinician and the pathologist. OCT was able to differential normal from pathological tissue and pathological tissue of different entities in this immediate ex vivo study. Unfortunately, OCT provided inadequate cellular and subcellular information to enable the grading of oral premalignant disorders.
conclusionThis study enabled the creation of OCT bank of normal and pathological oral tissues. The pathological changes identified using OCT enabled differentiation between normal and pathological tissues, and identification of different tissue pathologies. Further studies are required to assess the accuracy of OCT in identification of various pathological processes involving the oral tissues.
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