ReviewCurrent opinion in chemical biology2012
Directed evolution: an evolving and enabling synthetic biology tool.
Review in Current opinion in chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Open-endedness in synthetic biology: A route to continual innovation for biological design.Science advances · 2024Review
- Biosensor development for single-cell detection of glucuronate.Journal of industrial microbiology & biotechnology · 2023Article
- Research progress of pathway and genome evolution in microbes.Synthetic and systems biotechnology · 2022Article
- Looking Back: A Short History of the Discovery of Enzymes and How They Became Powerful Chemical Tools.ChemCatChem · 2020Review
- Kinetic characterization and structure analysis of an altered polyol dehydrogenase with d-lactate dehydrogenase activity.Protein science : a publication of the Protein Society · 2020Article
- Genetically Engineered Proteins to Improve Biomass Conversion: New Advances and Challenges for Tailoring Biocatalysts.Molecules (Basel, Switzerland) · 2019Review
- GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries.ACS synthetic biology · 2019Article
- Thirty-degree shift in optimum temperature of a thermophilic lipase by a single-point mutation: effect of serine to threonine mutation on structural flexibility.Molecular and cellular biochemistry · 2017Article
- Functional Site Discovery in a Sulfur Metabolism Enzyme by Using Directed Evolution.Chembiochem : a European journal of chemical biology · 2016Article
- CRMAGE: CRISPR Optimized MAGE Recombineering.Scientific reports · 2016Article
- Systems strategies for developing industrial microbial strains.Nature biotechnology · 2015Review
- Economical analysis of saturation mutagenesis experiments.Scientific reports · 2015Article
- High Throughput Screening and Selection Methods for Directed Enzyme Evolution.Industrial & engineering chemistry research · 2015Review
- Directed evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomes.Bioengineered · 2015Review
- Combinatorial Screening for Transgenic Yeasts with High Cellulase Activities in Combination with a Tunable Expression System.PloS one · 2015Article
- Protein design for pathway engineering.Journal of structural biology · 2014Review
- Bridging the gap: a roadmap to breaking the biological design barrier.Frontiers in bioengineering and biotechnology · 2014Review
- Mutagenic Organized Recombination Process by Homologous IN vivo Grouping (MORPHING) for directed enzyme evolution.PloS one · 2014Article
- DNA catalysts with tyrosine kinase activity.Journal of the American Chemical Society · 2013Article
- Directed Evolution: Past, Present and Future.AIChE journal. American Institute of Chemical Engineers · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Synthetic biology, with its goal of designing biological entities for wide-ranging purposes, remains a field of intensive research interest. However, the vast complexity of biological systems has heretofore rendered rational design prohibitively difficult. As a result, directed evolution remains a valuable tool for synthetic biology, enabling the identification of desired functionalities from large libraries of variants. This review highlights the most recent advances in the use of directed evolution in synthetic biology, focusing on new techniques and applications at the pathway and genome scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.