ArticleAging cell2012
Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis.
Article in Aging cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Association between the Fibrosis-4 index and mortality risk in acute pancreatitis.Frontiers in medicine · 2026Article
- Article
- Characteristic of pancreatic involvement in melioidosis: Case report and literature review.Heliyon · 2024Article
- Age-Related Decline in Pancreas Regeneration Is Associated With an Increased Proinflammatory Response to Injury.Gastro hep advances · 2024Article
- Administration of Warfarin Inhibits the Development of Cerulein-Induced Edematous Acute Pancreatitis in Rats.Biomolecules · 2023Article
- Visceral fat-specific regulation of plasminogen activator inhibitor-1 in aged septic mice.Journal of cellular physiology · 2022Article
- Divergent Sepsis Pathophysiology in Older Adults.Antioxidants & redox signaling · 2021Review
- Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson's Disease and Parkinsonism.International journal of molecular sciences · 2018Review
- Late Therapeutic Intervention with Antibiotics and Fluid Resuscitation Allows for a Prolonged Disease Course with High Survival in a Severe Murine Model of Sepsis.Shock (Augusta, Ga.) · 2017Article
- Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats.Clinical interventions in aging · 2017Article
- Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.Experimental gerontology · 2016Article
- Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1.Experimental and therapeutic medicine · 2015Article
- High-mobility group box 1 protein and its role in severe acute pancreatitis.World journal of gastroenterology · 2015Review
- Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.American journal of physiology. Heart and circulatory physiology · 2015Article
- Sepsis in old age: review of human and animal studies.Aging and disease · 2014Review
- A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis.PloS one · 2014Article
- Article
- The clinical course of acute pancreatitis and the inflammatory mediators that drive it.International journal of inflammation · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The severity and mortality rates of acute pancreatitis (AP) are significantly elevated in the elderly population. However, due to a lack of appropriate animal models, the underlying mechanisms for this age-dependent vulnerability remain largely unknown. The purpose of this study was to characterize a murine model of AP, which displays age-associated severity, and to use this model to identify pathophysiologies that are distinctive of the aged with AP. AP was induced in young (4-5 months), middle-aged (12-13 months), and aged (23-25 months) C57BL/6 mice by repeated injection of caerulein, a homologue of the gastrointestinal hormone cholecystokinin. Approximately 10% of aged mice died during AP, while young and middle-aged mice showed no mortality. Although both young and aged mice exhibited early signs of edema and inflammation in the pancreas, kidney, and lung, young mice showed signs of recovery within 24 h, while aged mice exhibited increasingly severe tissue damage and cell death. There was a significant age-dependent increase in pancreatic neutrophil activation and systemic inflammation as assessed by pancreatic myeloperoxidase and plasma interleukin-6 (IL-6) concentration, respectively. Importantly, aged but not young mice with AP showed significantly elevated thrombosis in the lung and kidney as well as a marked increase in plasma concentration of plasminogen activator inhibitor-1 (PAI-1), a primary inhibitor of the fibrinolytic system. These results demonstrate that aging is associated with increased severity of AP characterized by augmented and prolonged pancreatic inflammation and the presence of multiple extra-pancreatic sequelae including thrombosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.