ArticleBMC neuroscience2012
Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury.
Article in BMC neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 0 citations in OpenAlex.
- Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.Cell reports · 2020Article
- Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis.Human molecular genetics · 2018Article
- Optic nerve as a source of activated retinal microglia post-injury.Acta neuropathologica communications · 2018Article
- JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.Cell death & disease · 2017Article
- Attenuation of Axonal Degeneration by Calcium Channel Inhibitors Improves Retinal Ganglion Cell Survival and Regeneration After Optic Nerve Crush.Molecular neurobiology · 2017Article
- Intraocular Injection of ES Cell-Derived Neural Progenitors Improve Visual Function in Retinal Ganglion Cell-Depleted Mouse Models.Frontiers in cellular neuroscience · 2017Article
- Promotion of axon regeneration and inhibition of astrocyte activation by alpha A-crystallin on crushed optic nerve.International journal of ophthalmology · 2016Article
- DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.Neurobiology of disease · 2014Article
- Wallerian degeneration: an emerging axon death pathway linking injury and disease.Nature reviews. Neuroscience · 2014Review
- Article
- Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts.PloS one · 2014Article
- Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons.Investigative ophthalmology & visual science · 2013Article
- Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundWe have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats. To test the effects of a combination approach protecting both axons and cell bodies we performed combined optic nerve crush and lens injury, which results in both enhanced RGC survival as well as axon regeneration past the lesion site in wildtype animals.
resultsAs previously reported we found that the Wld(S) mutation does not protect RGC bodies after optic nerve crush alone. Surprisingly, we found that Wld(S) transgenic rats did not exhibit the enhanced RGC survival response after combined optic nerve crush and lens injury that was observed in wildtype rats. RGC axon regeneration past the optic nerve lesion site was, however, similar in Wld(S) and wildtypes. Furthermore, activation of retinal glia, previously shown to be associated with enhanced RGC survival and axon regeneration after optic nerve crush and lens injury, was unaffected in Wld(S) transgenic rats.
conclusionsRGC axon regeneration is similar between Wld(S) transgenic and wildtype rats, but Wld(S) transgenic rats do not exhibit enhanced RGC survival after combined optic nerve crush and lens injury suggesting that the neuroprotective effects of lens injury on RGC survival may be limited by the Wld(S) protein.
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