ArticleTraffic (Copenhagen, Denmark)2012
Tuning multiple motor travel via single motor velocity.
Article in Traffic (Copenhagen, Denmark), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Heterogeneous distribution of kinesin-streptavidin complexes revealed by mass photometry.Soft matter · 2024Article
- Competition between physical search and a weak-to-strong transition rate-limits kinesin binding times.PLoS computational biology · 2024Article
- A new method to experimentally quantify dynamics of initial protein-protein interactions.Communications biology · 2024Article
- ADP release can explain spatially-dependent kinesin binding times.bioRxiv : the preprint server for biology · 2023Article
- Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- On the use of thermal forces to probe kinesin's response to force.Frontiers in molecular biosciences · 2023Article
- Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors.PLoS computational biology · 2022Article
- Tuning ensemble-averaged cargo run length via fractional change in mean kinesin number.Physical biology · 2021Article
- Dynein self-organizes while translocating the centrosome in T-cells.Molecular biology of the cell · 2021Article
- Force Generated by Two Kinesin Motors Depends on the Load Direction and Intermolecular Coupling.Physical review letters · 2019Article
- Cargo diffusion shortens single-kinesin runs at low viscous drag.Scientific reports · 2019Article
- Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level.Nature communications · 2018Article
- Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers.Biophysical journal · 2018Article
- A fluid membrane enhances the velocity of cargo transport by small teams of kinesin-1.The Journal of chemical physics · 2018Article
- Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.Nature structural & molecular biology · 2018Article
- Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport.Biophysical journal · 2018Article
- Mechanical coupling of microtubule-dependent motor teams during peroxisome transport in Drosophila S2 cells.Biochimica et biophysica acta. General subjects · 2017Article
- Heterogeneity in kinesin function.Traffic (Copenhagen, Denmark) · 2017Article
- Native kinesin-1 does not bind preferentially to GTP-tubulin-rich microtubules in vitro.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Single Molecule Investigation of Kinesin-1 Motility Using Engineered Microtubule Defects.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.