ArticleCNS neuroscience & therapeutics2012
Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring.
Article in CNS neuroscience & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Neuroendocrine pathogenesis of perimenopausal depression.Frontiers in psychiatry · 2023Review
- Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders.Frontiers in aging neuroscience · 2022Review
- Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats.Experimental neurobiology · 2021Article
- Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders.Frontiers in psychiatry · 2021Article
- LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression.Bioscience reports · 2020Article
- Brain NMDA Receptors in Schizophrenia and Depression.Biomolecules · 2020Review
- Affective Immunology: The Crosstalk Between Microglia and Astrocytes Plays Key Role?Frontiers in immunology · 2020Review
- Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder.The international journal of neuropsychopharmacology · 2019Article
- The Impact and Mechanism of Methylated Metabotropic Glutamate Receptors 1 and 5 in the Hippocampus on Depression-Like Behavior in Prenatal Stress Offspring Rats.Journal of clinical medicine · 2018Article
- Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity.Psychopharmacology · 2015Article
- Establishment of depression behavioral criteria in cynomolgus monkeys.CNS neuroscience & therapeutics · 2013Article
- From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.Biological psychiatry · 2013Review
- Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders.Neuroendocrinology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe present study was to understand whether early adult depressive females implicated their offspring.
methodsSeven-week-old female mice were subject to chronic mild stress (CMS) to establish the animal model of depression. The behavioral performance of their offspring were tested via neonatal reflexes tests, hole-board test, and morris water maze test in different ages. Astrocyte number, hippocampal volume, and neurogenesis were analyzed via immunohistochemical blotting. Glucocorticoid receptor (GR) expression and serum cortisol levels were measured by western blotting and ELISA.
resultsFemale depressive mice had normal fertility, but their offspring had lowered neonatal survival rate and body weight from neonatal period to early adulthood. The offspring of female depressive mice exhibited the impairments of neonatal reflex attainment and memory, but had higher emotionality as adults. Furthermore, the astrocyte number, hippocampal volume, and neurogenesis were reduced in the offspring. However, the expressions of GR were increased in the hippocampus of offspring.
conclusionThis study reveals that female early adult depressive mice have normal reproductive ability, but make long-term detrimental impacts on the behavioral performance and brain development of their offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.