ArticleInfluenza and other respiratory viruses2012
Intensive care unit patients with 2009 pandemic influenza A (H1N1pdm09) virus infection - United States, 2009.
Article in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
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- Eosinophils as potential biomarkers in respiratory viral infections.Frontiers in immunology · 2023Review
- Could Interleukin-33 (IL-33) Govern the Outcome of an Equine Influenza Virus Infection? Learning from Other Species.Viruses · 2021Review
- Outcomes among critically ill adults with influenza infection.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- Assessment of the Association of COPD and Asthma with In-Hospital Mortality in Patients with COVID-19. A Systematic Review, Meta-Analysis, and Meta-Regression Analysis.Journal of clinical medicine · 2021Review
- Clinical Characteristics and Predictors of Mortality in Critically Ill Adult Patients with Influenza Infection.International journal of environmental research and public health · 2021Article
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- Respiratory tract infections in children with allergic asthma on allergen immunotherapy during influenza season.Scientific reports · 2021Article
- Understanding building-occupant-microbiome interactions toward healthy built environments: A review.Frontiers of environmental science & engineering · 2021Review
- Influenza A virus directly modulates mouse eosinophil responses.Journal of leukocyte biology · 2020Article
- Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice.Scientific reports · 2019Article
- Spectrum of clinical and radiographic findings in patients with diagnosis of H1N1 and correlation with clinical severity.BMC infectious diseases · 2019Article
- Article
- Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice.Scientific reports · 2019Article
- Imaging of Emerging Infectious Diseases.Current radiology reports · 2019Review
- The Role of Innate Leukocytes during Influenza Virus Infection.Journal of immunology research · 2019Review
- Influenza in Asthmatics: For Better or for Worse?Frontiers in immunology · 2018Review
- Humoral immune responses during asthma and influenza co-morbidity in mice.Immunobiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe influenza A (H1N1pdm09) [pH1N1] virus resulted in intensive care unit (ICU) admissions, acute respiratory distress syndrome (ARDS), and death.
objectivesTo describe the characteristics of ICU patients with pH1N1 virus infection in the United States during the spring and fall of 2009 and to describe the factors associated with severe complications including ARDS and death. PATIENTS/
methodsThrough two national case-series conducted during spring and fall of 2009, medical charts were reviewed on ICU patients with laboratory-confirmed pH1N1 infection by real-time reverse-transcriptase polymerase chain reaction.
resultsThe majority (77%) of 154 patients hospitalized in an ICU were <50 years of age, and 65% had at least one underlying medical condition. One hundred and twenty-eight (83%) patients received influenza antiviral agents; 29% received treatment ≤ 2 days after illness onset. Forty-eight (38%) patients developed ARDS and 37 (24%) died. Patients with ARDS were more likely to be morbidly obese (36% versus 19%, P=0.04) and patients who died were less likely to have asthma (11% versus 28%, P=0.05). Compared with patients who received treatment ≥ 6 days after illness onset, patients treated ≤ 2 days after illness onset were less likely to develop ARDS (17% versus 37%, P<0.01) or die (7% versus 35%, P<0.01).
conclusionsAmong patients hospitalized in an ICU with pH1N1 virus infection, ARDS was a common complication, and one-quarter of patients died. Patients with asthma had less severe outcomes. Early treatment with influenza antiviral agents was likely beneficial, especially when initiated ≤ 2 days after illness onset.
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