ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2012
Biomarkers intersect with the exposome.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Welding Fume Exposure and Epigenetic Alterations: A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026Review
- Evaluation of spot urine CA 19 - 9/creatinine ratio in diagnosis and management of hydronephrosis in children: a prospective study.BMC pediatrics · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- ERS International Congress 2023: highlights from the Airway Diseases Assembly.ERJ open research · 2024Article
- [New advances in exposomics-analysis methods and research paradigms based on chromatography-mass spectrometry].Se pu = Chinese journal of chromatography · 2024Review
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy.Scientific reports · 2023Article
- Longitudinal early epigenomic signatures inform molecular paths of therapy response and remission in depressed patients.Frontiers in molecular neuroscience · 2023Article
- Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan.The Lancet. Respiratory medicine · 2022Review
- The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.Environmental toxicology and chemistry · 2022Article
- Defining the Exposome Using Popular Education and Concept Mapping With Communities in Atlanta, Georgia.Frontiers in public health · 2022Article
- Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.Environmental health perspectives · 2021Article
- [Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers].Se pu = Chinese journal of chromatography · 2021Article
- Human Health Exposure Analysis Resource (HHEAR): A model for incorporating the exposome into health studies.International journal of hygiene and environmental health · 2021Review
- High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity.Environment international · 2020Article
- Article
- Mapping the Human Exposome to Uncover the Causes of Breast Cancer.International journal of environmental research and public health · 2019Article
- Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium.Metabolites · 2019Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.