ArticleJournal of clinical hypertension (Greenwich, Conn.)2012
Antihypertensive drug use by children: are the drugs labeled and indicated?
Article in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Urine Sodium Excretion in Children with Primary Hypertension: A Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- Article
- Reliability of remote at-home oscillometric blood pressure monitoring in community-dwelling children aged 3-17.Frontiers in pediatrics · 2025Article
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.Kidney research and clinical practice · 2025Article
- Development and Validation of a Nomogram-Based Model to Predict Primary Hypertension Within the Next Year in Children and Adolescents: Retrospective Cohort Study.Journal of medical Internet research · 2024Article
- Hypertension in children and adolescents: perspectives in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Efficacy of fosinopril and amlodipine in pediatric primary hypertension: a single-center observational study.Frontiers in pediatrics · 2023Article
- Systematic Data Monitoring and Analysis of Cardiovascular Off-label Prescriptions in Pediatrics: Focus on Angiotensin-Converting Enzyme Inhibitors (ACE-I) and Beta Blockers.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Article
- A reappraisal of the prevalence of pediatric hypertension through a nationwide database in Taiwan.Scientific reports · 2021Article
- Pharmacologic Treatment of Pediatric Hypertension.Current hypertension reports · 2016Review
- Drug use in children hospitalized with cardio-rheumatologic diseases in Andijan, Uzbekistan: a cross-sectional descriptive study.BMC pharmacology & toxicology · 2016Article
- Pharmacologic Management of Pediatric Hypertension.Paediatric drugs · 2016Review
- Use of antihypertensive medications and diagnostic tests among privately insured adolescents and young adults with primary versus secondary hypertension.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Article
- Anti-hypertensive drugs in children and adolescents.World journal of cardiology · 2014Review
- Treatment strategies to prevent renal damage in hypertensive children.Current hypertension reports · 2014Review
- Hypertension in the teenager.Pediatric clinics of North America · 2014Review
- KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Article
- The changing face of pediatric hypertension in the era of the childhood obesity epidemic.Pediatric nephrology (Berlin, Germany) · 2013Review
- Treatment of obesity-related hypertension in children and adolescents.Current hypertension reports · 2013Review
- What is the optimal first-line agent in children requiring antihypertensive medication?Current hypertension reports · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
As a result of the Food and Drug Administration (FDA) Modernization Act and the Best Pharmaceuticals for Children Act, the number of medications with FDA-approved pediatric labeling has increased. To assess the success of these initiatives, we examined whether antihypertensive drugs used by children with hypertension in 2008 had FDA-approved pediatric labeling and indications. Using a nationwide commercial insurer database, 2915 children with primary (n=2607) and secondary (n=308) hypertension were identified. Drug user rate and days of supply were calculated from pharmacy claims. Drugs were categorized based on pediatric labeling and indication and whether they were recommended for pediatric use. Antihypertensive drugs were used by 889 (34%) children with primary hypertension and 200 children (65%) with secondary hypertension. User rates were 44.3% in hypertensive children younger than 6 years, 30.9% in those 6 years to older than 12 years, and 38.1% in those 12 years to older than 18 years. Seven percent of drugs were neither labeled for pediatric use nor considered recommended for use in children. In children younger than 6 years, 29% of drugs used were not indicated for use in that age group. Despite recent legislative initiatives, many drugs used by hypertensive children still lack pediatric labeling. Additional efforts are needed to close the gap between the availability of drugs that are labeled and indicated for pediatric use and actual drug usage in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.