ReviewBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy2012
Recommendations and considerations for the use of biologics in orthopedic surgery.
Review in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Evolution in Bone Tissue Regeneration: From Grafts to Innovative Biomaterials.International journal of molecular sciences · 2025Review
- A Review on Bone Tumor Management: Cutting-Edge Strategies in Bone Grafting, Bone Graft Substitute, and Growth Factors for Defect Reconstruction.Orthopedic research and reviews · 2025Review
- The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration.International journal of molecular sciences · 2024Review
- Limitations and modifications in the clinical application of calcium sulfate.Frontiers in surgery · 2024Review
- Influence of Ag and/or Sr Dopants on the Mechanical Properties and In Vitro Degradation of β-Tricalcium Phosphate-Based Ceramics.Materials (Basel, Switzerland) · 2023Article
- An Overview of Magnesium-Phosphate-Based Cements as Bone Repair Materials.Journal of functional biomaterials · 2023Review
- Investigation of Surface Layers on Biological and Synthetic Hydroxyapatites Based on Bone Mineralization Process.Biomimetics (Basel, Switzerland) · 2023Review
- [Synthetic bone replacement substances].Orthopadie (Heidelberg, Germany) · 2022Article
- A clinical trial of a unidirectional porous tricalcium phosphate filling for defects after resection of benign bone lesions: a prospective multicenter study.Scientific reports · 2022Article
- Recent Advances in Hydroxyapatite-Based Biocomposites for Bone Tissue Regeneration in Orthopedics.International journal of molecular sciences · 2022Review
- Sr and Mg Doped Bi-Phasic Calcium Phosphate Macroporous Bone Graft Substitutes Fabricated by Robocasting: A Structural and Cytocompatibility Assessment.Journal of functional biomaterials · 2022Article
- (Bio)manufactured Solutions for Treatment of Bone Defects with Emphasis on US-FDA Regulatory Science Perspective.Advanced nanobiomed research · 2022Article
- Current Modalities for Fracture Healing Enhancement.Tissue engineering and regenerative medicine · 2022Review
- Forearm Plate Fixation: Should Plates Be Removed?The archives of bone and joint surgery · 2022Article
- Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review.Materials (Basel, Switzerland) · 2022Review
- FDA-approved bone grafts and bone graft substitute devices in bone regeneration.Materials science & engineering. C, Materials for biological applications · 2021Review
- Article
- Graphene and its Derivatives for Bone Tissue Engineering:Frontiers in bioengineering and biotechnology · 2021Review
- Graphene-Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation.Advanced healthcare materials · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Reconstruction of extensive bone defects remains technically challenging and has considerable medical and financial impact on our society. Surgical procedures often require a bone/substitute graft to enhance and accelerate bone repair. Bone autografts are associated with morbidity related to bone harvesting and are limited in quantity. Alternatively, bone allografts expose the patient to the risk of transmission of infectious disease. Synthetic bone graft substitutes, such as calcium sulfates, hydroxyapatite, tricalcium phosphate, and combinations, circumvent some of the disadvantages of auto- and allografts, but have limited indications. Biomedical research has made possible the stimulation of the body's own healing mechanisms, either by delivering exogenous growth factors locally, or by stimulating their local production by gene transfer. Among all known factors having osteoinductive properties, only two bone morphogenetic proteins (for specific indications) and demineralized bone matrix have been approved for clinical use. In addition, ongoing research is exploring the efficacy of cell therapy and tissue engineering. The present report examines the composition, biological properties, indications, clinical experience and regulations of several of the biotherapeutics employed for bone reconstruction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.