ArticleJournal of clinical periodontology2012
MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
Article in Journal of clinical periodontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Assessment of salivary matrix metalloproteinase (MMP8) and activated salivary matrix metalloproteinase (aMMP8) in periodontitis patients: a systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.Scientific reports · 2016Pooled it
- Association of Common Variants in MMPs with Periodontitis Risk.Disease markers · 2016Pooled it
- Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis.Scientific reports · 2015Pooled it
- A Study ofBioMed research international · 2017Trial
- CB2 Receptor Activation Attenuates IL-1β-Induced Inflammatory Transcriptomic Networks in Human Gingival Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Upregulation of MMP3 Promotes Cisplatin Resistance in Ovarian Cancer.International journal of molecular sciences · 2025Article
- Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy.International journal of molecular sciences · 2025Review
- Immune Dysregulation in the Oral Cavity during Early SARS-CoV-2 Infection.Journal of dental research · 2024Article
- Association between matrix metalloproteinase-3 gene polymorphism and susceptibility to chronic periodontitis: A systematic review and meta-analysis.Journal of medical biochemistry · 2024Article
- Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review.GMS hygiene and infection control · 2024Review
- Evaluation of matrix metalloproteinase-1, -2, -3, -7, and -13 gene polymorphisms in patients with chronic periodontitis and healthy controls.Clinical oral investigations · 2023Article
- Nociceptors regulate osteoimmune transcriptomic response to infection.Scientific reports · 2023Article
- Genome-wide Association Study Identifies Novel Risk Loci for Apical Periodontitis.Journal of endodontics · 2023Article
- Matrix Metalloproteinases in Oral Health-Special Attention on MMP-8.Biomedicines · 2023Review
- Genome-wide association study identifies novel risk loci for apical periodontitis.Research square · 2023Article
- Evaluation of Gene Polymorphism and Gingival Crevicular Fluid Levels of Matrix Metalloproteinase-3 in a Group of Turkish Periodontitis Patients.Pathogens (Basel, Switzerland) · 2021Article
- The Role of Matrix Metalloproteinases in Periodontal Disease.International journal of environmental research and public health · 2020Review
- Gene coexpression analysis reveals dose-dependent and type-specific networks responding to ionizing radiation in the aquatic model plantJournal of genetics · 2019Article
- Are mTOR and Endoplasmic Reticulum Stress Pathway Genes Associated with Oral and Bone Diseases?Caries research · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
aimMatrix metalloproteinases (MMPs) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of MMP and TIMP polymorphisms with chronic periodontitis in two populations. MATERIAL AND
methodsA total of 34 polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic periodontitis and 302 controls), and 274 individuals from the US (70 cases and 204 controls). Individuals were considered cases if presenting at least three teeth exhibiting sites of clinical attachment loss ≥ 5 mm in two different quadrants. Controls were characterized by absence of clinical attachment loss and no sites with probing depth >3 mm. MMP3 and TIMP1 mRNA expression was evaluated in healthy and diseased periodontal tissues.
resultsTIMP1 showed association with chronic periodontitis in the Brazilian population (for rs5906435, p = 0.0004), whereas MMP3 showed association in the US population (for rs679620, p = 0.0003; and rs650108, p = 0.002) and in the Brazilian population (for rs639752, p = 0.005). MMP3 and TIMP1 mRNA expression was significantly higher in diseased tissues when compared to control tissues.
conclusionsOur results further support a role for variations in MMP3 in chronic periodontitis and report a novel association with TIMP1. These genes may be considered additional candidate genes for chronic periodontitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.