ArticleInterface focus2011
Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design.
Article in Interface focus, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model.Annals of biomedical engineering · 2024Article
- A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics.Journal of the Royal Society, Interface · 2022Article
- Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling.Journal of the Royal Society, Interface · 2022Article
- Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: A simulation study with computational fluid dynamics modeling.Frontiers in neurology · 2022Article
- Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.PloS one · 2022Article
- A homogenized constrained mixture model of restenosis and vascular remodelling after balloon angioplasty.Journal of the Royal Society, Interface · 2021Article
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments.Cardiovascular engineering and technology · 2019Article
- Semi-intrusive multiscale metamodelling uncertainty quantification with application to a model of in-stent restenosis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Preliminary outcomes of single antiplatelet therapy for surface-modified flow diverters in an animal model: analysis of neointimal development and thrombus formation using OCT.Journal of neurointerventional surgery · 2019Article
- Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis.Cardiovascular engineering and technology · 2018Article
- Predictive Physiological Modeling of Percutaneous Coronary Intervention - Is Virtual Treatment Planning the Future?Frontiers in physiology · 2018Review
- A cell-based mechanical model of coronary artery tunica media.Journal of the Royal Society, Interface · 2017Article
- A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations toFrontiers in physiology · 2017Article
- Towards the virtual artery: a multiscale model for vascular physiology at the physics-chemistry-biology interface.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting.Journal of the Royal Society, Interface · 2015Article
- Effects of endothelium, stent design and deployment on the nitric oxide transport in stented artery: a potential role in stent restenosis and thrombosis.Medical & biological engineering & computing · 2015Article
- A framework for multi-scale modelling.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
- Performance of distributed multiscale simulations.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
- Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neointimal hyperplasia, a process of smooth muscle cell re-growth, is the result of a natural wound healing response of the injured artery after stent deployment. Excessive neointimal hyperplasia following coronary artery stenting results in in-stent restenosis (ISR). Regardless of recent developments in the field of coronary stent design, ISR remains a significant complication of this interventional therapy. The influence of stent design parameters such as strut thickness, shape and the depth of strut deployment within the vessel wall on the severity of restenosis has already been highlighted but the detail of this influence is unclear. These factors impact on local haemodynamics and vessel structure and affect the rate of neointima formation. This paper presents the first results of a multi-scale model of ISR. The development of the simulated restenosis as a function of stent deployment depth is compared with an in vivo porcine dataset. Moreover, the influence of strut size and shape is investigated, and the effect of a drug released at the site of injury, by means of a drug-eluting stent, is also examined. A strong correlation between strut thickness and the rate of smooth muscle cell proliferation has been observed. Simulation results also suggest that the growth of the restenotic lesion is strongly dependent on the stent strut cross-sectional profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.