ArticleScience signaling2012
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors.
Article in Science signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Post-myocardial Infarction Cardiac Remodeling: Multidimensional Mechanisms and Clinical Prospects of Stem Cell Therapy.Stem cell reviews and reports · 2025Review
- Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review.Biomaterials research · 2023Review
- Differential contractility regulates cancer stem cell migration.Biophysical journal · 2023Article
- Tracing the cis-regulatory changes underlying the endometrial control of placental invasion.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture.ACS biomaterials science & engineering · 2021Review
- Review
- Environmental Elasticity Regulates Cell-type Specific RHOA Signaling and Neuritogenesis of Human Neurons.Stem cell reports · 2019Article
- Dynamic secretome of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Matrix Rigidity-Dependent Regulation of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells.Scientific reports · 2019Article
- Bone physiology as inspiration for tissue regenerative therapies.Biomaterials · 2018Review
- Evaluation of Hydrogels Presenting Extracellular Matrix-Derived Adhesion Peptides and Encapsulating Cardiac Progenitor Cells for Cardiac Repair.ACS biomaterials science & engineering · 2018Article
- Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.Journal of the American Heart Association · 2017Article
- Spatiotemporally Controlled Mechanical Cues Drive Progenitor Mesenchymal-to-Epithelial Transition Enabling Proper Heart Formation and Function.Current biology : CB · 2017Article
- A biomaterial approach to cell reprogramming and differentiation.Journal of materials chemistry. B · 2017Article
- Regulation of cell proliferation by hypoxia-inducible factors.American journal of physiology. Cell physiology · 2015Review
- Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues.Biomaterials · 2015Article
- Three-dimensional, soft neotissue arrays as high throughput platforms for the interrogation of engineered tissue environments.Biomaterials · 2015Article
- A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2015Article
- Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis.ACS nano · 2015Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Tissue development and regeneration involve tightly coordinated and integrated processes: selective proliferation of resident stem and precursor cells, differentiation into target somatic cell type, and spatial morphological organization. The role of the mechanical environment in the coordination of these processes is poorly understood. We show that multipotent cells derived from native cardiac tissue continually monitored cell substratum rigidity and showed enhanced proliferation, endothelial differentiation, and morphogenesis when the cell substratum rigidity closely matched that of myocardium. Mechanoregulation of these diverse processes required p190RhoGAP, a guanosine triphosphatase-activating protein for RhoA, acting through RhoA-dependent and -independent mechanisms. Natural or induced decreases in the abundance of p190RhoGAP triggered a series of developmental events by coupling cell-cell and cell-substratum interactions to genetic circuits controlling differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.