ArticleDevelopment (Cambridge, England)2012
A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.Cellular oncology (Dordrecht, Netherlands) · 2024Article
- Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB.Nature communications · 2023Article
- TGFβ inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.Scientific reports · 2023Article
- Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation.Gene expression patterns : GEP · 2023Article
- Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways.Biological research · 2019Article
- Mechanisms of Wnt signaling and control.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning.Developmental biology · 2018Article
- Vertebrate Axial Patterning: From Egg to Asymmetry.Advances in experimental medicine and biology · 2017Review
- Go ahead, grow a head! A planarian's guide to anterior regeneration.Regeneration (Oxford, England) · 2016Review
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- An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex.eLife · 2016Article
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- Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain.Development (Cambridge, England) · 2015Article
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- microRNA regulation of Wnt signaling pathways in development and disease.Cellular signalling · 2015Review
- Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.Developmental cell · 2015Article
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- Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.Developmental biology · 2014Article
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- Differential responses to Wnt and PCP disruption predict expression and developmental function of conserved and novel genes in a cnidarian.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Multiple developmental processes require tightly controlled Wnt signaling, and its misregulation leads to congenital abnormalities and diseases. Glypicans are extracellular proteins that modulate the Wnt pathway. In addition to interacting with Wnts, these glycosophosphotidylinositol (GPI)-anchored, heparan-sulfate proteoglycans bind ligands of several other signaling pathways in both vertebrates and invertebrates. In Drosophila, Notum, a secreted α/β-hydrolase, antagonizes the signaling of the prototypical Wnt Wingless (Wg), by releasing glypicans from the cell surface. Studies of mammalian Notum indicate promiscuous target specificity in cell culture, but the role of Notum in vertebrate development has not been studied. Our work shows that zebrafish Notum 1a, an ortholog of mammalian Notum, contributes to a self-regulatory loop that restricts Wnt/β-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity (PCP) pathway. Our results suggest a surprising specific role of Notum in the developing vertebrate embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.