ArticleParasitology research2012
Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Leishmaniasis and Trace Element Alterations: a Systematic Review.Biological trace element research · 2021Pooled it
- Assessment of Oxidative Stress and DNA Damage in Dogs with Visceral Leishmaniasis Using Urinary 8-Hydroxy-2'-Deoxyguanosine.Veterinary sciences · 2026Article
- Hematological and Biochemical Outcomes of Leishmania Infantum Infection in the South American Coati (Nasua nasua) in an Endemic Area of Visceral Leishmaniasis in Central Western Brazil.Acta parasitologica · 2026Article
- Malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in canine serum: establishing reference intervals and influencing factors.BMC veterinary research · 2025Article
- Serum total antioxidant status in dogs: Reference intervals and influence of multiple biological and analytical factors.Veterinary clinical pathology · 2024Article
- Oxidative Stress in Canine Diseases: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2024Review
- The Interaction of Zinc as an Essential Trace Element withAdvanced biomedical research · 2024Review
- Zinc and Manganese Imbalances in BALB/c Mice Experimentally Infected with Leishmania (Leishmania) amazonensis.Acta parasitologica · 2023Article
- Relationships between the Content of Micro- and Macroelements in Animal Samples and Diseases of Different Etiologies.Animals : an open access journal from MDPI · 2023Article
- Vitamins A and D and Zinc Affect the Leshmanicidal Activity of Canine Spleen Leukocytes.Animals : an open access journal from MDPI · 2021Article
- Zinc in Dog Nutrition, Health and Disease: A Review.Animals : an open access journal from MDPI · 2021Review
- Clinical Significance of ROMs, OXY, SHp and HMGB-1 in Canine Leishmaniosis.Animals : an open access journal from MDPI · 2021Article
- Redox Status in Canine Leishmaniasis.Animals : an open access journal from MDPI · 2021Article
- Article
- ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs.Journal of veterinary internal medicine · 2019Article
- An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy.Frontiers in cellular and infection microbiology · 2019Review
- Biomarkers Associated WithFrontiers in cellular and infection microbiology · 2018Review
- Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control.BioMed research international · 2018Review
- Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice.International journal of environmental research and public health · 2017Article
- The role of apoptosis in the cellular response of liver and spleen of BALB/c mice in cutaneous leishmaniasis.Iranian journal of medical sciences · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the role of oxidative stress in the pathology of canine visceral leishmaniasis (CVL). We therefore studied the relationships between oxidative stress markers, liver and kidney variables, trace elements, and clinical status in dogs naturally infected with Leishmania infantum. Two groups of Leishmania-infected dogs [asymptomatic (AD, n = 14) and symptomatic (SD, n = 16)] were assessed and compared with a group of non-infected control dogs (CD, n = 30). A significant decrease (p < 0.001) in serum total antioxidant status (TAS) and albumin concentration (p < 0.05) and a significant increase in serum malondialdehyde (MDA) and blood urea nitrogen (BUN) concentrations (p < 0.001), in the SD group, were observed when compared to CD and AD groups. Dogs of the AD group presented a significant decrease in copper (p < 0.01) and zinc (p < 0.001) concentrations, when compared to CD group, while the SD group presented a significant decrease (p < 0.001) in copper and zinc concentrations, when compared to CD and AD groups. Oxidative stress markers (MDA and TAS) showed significant correlations (p < 0.001) with trace elements (copper and zinc) and liver (alanine aminotransferase) and kidney (BUN and creatinine) variables. The results of the present study revealed that symptomatic dogs showed more severe oxidative stress than asymptomatic and non-infected dogs and enhanced lipid peroxidation may be linked to liver and kidney damage in canine visceral leishmaniasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.