ArticleEuropean journal of pediatrics2012
Reduced cardiac output and its correlation with coronary blood flow and troponin in asphyxiated infants treated with therapeutic hypothermia.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Clinical, Electrocardiographic, Biochemical, and Echocardiographic Markers for Diagnosing Cardiac Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Influence of skin to skin contact on cardiac indices and cerebral perfusion-oxygenation in severely asphyxiated infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Left ventricular mass in newborn with perinatal asphxia: Assessment of allometric relations and impact of birth weight.World journal of clinical cases · 2026Article
- Cardiac biomarkers predict low right ventricle performance in neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Fetal cardiac troponin I levels decline toward birth in sheep.American journal of physiology. Heart and circulatory physiology · 2024Article
- Troponin I, CK-MB, and inotropic score in hypoxic-ischemic encephalopathy and associated infant mortality.BMC pediatrics · 2023Article
- The left ventricle in well newborns versus those with perinatal asphyxia, haemodynamically significant ductus arteriosus or fetal growth restriction.Translational pediatrics · 2023Review
- Left ventricular dysfunction in the newborn.Translational pediatrics · 2023Article
- Perinatal asphyxia and hypothermic treatment from the endocrine perspective.Frontiers in endocrinology · 2023Review
- Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps.Frontiers in pediatrics · 2023Review
- The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups-An Investigation Using Physiologically Based Pharmacokinetic Modelling.Pharmaceutics · 2022Article
- Pathophysiology of Perinatal Asphyxia in Humans and Animal Models.Biomedicines · 2022Review
- Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System.Frontiers in pediatrics · 2020Review
- Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants.PloS one · 2019Observational
- Application of Neonatologist Performed Echocardiography in the Assessment and Management of Neonatal Heart Failure unrelated to Congenital Heart Disease.Pediatric research · 2018Review
- Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study.BMC pediatrics · 2018Observational
- Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo.Physiological reports · 2017Article
- Cardiac injury biomarkers in paediatric age: Are we there yet?Heart failure reviews · 2016Review
- Cardiovascular Alterations and Multiorgan Dysfunction After Birth Asphyxia.Clinics in perinatology · 2016Review
- Cyclooxygenase inhibitors in preterm infants with patent ductus arteriosus: effects on cardiac and vascular indices.Pediatric cardiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perinatal asphyxia can lead to multi-organ insult which includes cardiovascular dysfunction. The objective was to study the relationship between cardiac function, perfusion and troponin. Unit database was accessed to identify infants with perinatal asphyxia over the last 2 years. Information from medical records and archived echocardiographic images was retrieved. Comparisons for echocardiographic information were made with healthy term infants. Seventeen infants with perinatal asphyxia were identified, of which three were excluded (one-33 weeks gestation, two-coagulopathy and pulmonary hypertension); 14 infants received therapeutic hypothermia. Median (range) gestation and birthweight were 39 (37-42) weeks and 3,550 (2,380-3,992) g respectively. Mean (S.D.) rectal temperature and time of echocardiogram were 33.5 ± 0.5 °C and median (range) 7.7 h [3-10] respectively. Majority of infants had low biventricular outputs. Median (range) SVC flow was 29.8 ml/kg/min (13-96.2). Median (range) troponin was 0.77 μg/L (0.17-2.6); normal ≤ 0.08 μg/L. Markedly low coronary flows (diastolic VTI median (range) 2.1 (1.3-2.9) cm were noted compared to controls. Coronary flow had a significantly positive correlation with left ventricular output. Higher troponin levels were associated with lower aortic stroke velocity. A close association between cardiac output, perfusion and troponin was noted. A dichotomy between blood pressure and flow parameters was noted, indicating the wide variation in vascular resistance in these infants. Biventricular output, coronary and SVC flows were significantly higher in the control population. In conclusion, inter-variable relationship between cardiac output, coronary flow and troponin is an important addition to the understanding of cardiovascular impact of perinatal asphyxia.
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