ArticleMolecular systems biology2012
A genomic bias for genotype-environment interactions in C. elegans.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Genotype by Environment Interactions in Gene Regulation Underlie the Response to Soil Drying in the Model Grass Brachypodium distachyon.Molecular biology and evolution · 2025Article
- Genetic Variants Affecting FADS2 Enzyme Dynamics and Gene Expression in Cogenetic Oysters with Different PUFA Levels Provide New Tools to Improve Unsaturated Fatty Acids.International journal of molecular sciences · 2024Article
- Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae.Nature ecology & evolution · 2024Article
- ThemBio · 2024Article
- Cis- and Trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species.Molecular biology and evolution · 2023Article
- The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues.G3 (Bethesda, Md.) · 2022Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Article
- Multivariable regulation of gene expression plasticity in metazoans.Open biology · 2019Article
- Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.Nature communications · 2019Article
- Genomics of Developmental Plasticity in Animals.Frontiers in genetics · 2019Review
- C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.BMC biology · 2017Article
- Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.American journal of human genetics · 2016Article
- Article
- Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.Nature communications · 2015Article
- Natural RNA interference directs a heritable response to the environment.Scientific reports · 2014Article
- Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.Genome research · 2014Article
- Transient and permanent experience with fatty acids changes Drosophila melanogaster preference and fitness.PloS one · 2014Article
- A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2.PloS one · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotype of an organism is determined by its genotype and environment. An interaction between these two arises from the differential effect of the environment on gene expression in distinct genotypes; however, the genomic properties identifying these are not well understood. Here we analyze the transcriptomes of five C. elegans strains (genotype) cultivated in five growth conditions (environment), and find that highly regulated genes, as distinguished by intergenic lengths, motif concentration, and expression levels, are particularly biased toward genotype-environment interactions. Sequencing these strains, we find that genes with expression variation across genotypes are enriched for promoter single-nucleotide polymorphisms (SNPs), as expected. However, genes with genotype-environment interactions do not significantly differ from background in terms of their promoter SNPs. Collectively, these results indicate that the highly regulated nature of particular genes predispose them for exhibiting genotype-environment interaction as a consequence of changes to upstream regulators. This observation may provide a deeper understanding into the origin of the extraordinary gene expression diversity present in even closely related species.
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