ArticleAge (Dordrecht, Netherlands)2013
Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.
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Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- The effect of multi-component exercise on cognition function in patients with diabetes: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Sex Differences in Physical Activity and Incident Stroke: A Systematic Review.Clinical therapeutics · 2022Pooled it
- A Systematic Review of the Impact of Physical Exercise-Induced Increased Resting Cerebral Blood Flow on Cognitive Functions.Frontiers in aging neuroscience · 2022Pooled it
- The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.Scientific reports · 2023Trial
- Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Association between cardiorespiratory fitness and cerebrovascular reactivity to a breath-hold stimulus in older adults: influence of aerobic exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Trial
- One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Can exercise training enhance the repeated remote ischaemic preconditioning stimulus on peripheral and cerebrovascular function in high-risk individuals?European journal of applied physiology · 2021Trial
- The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Trial
- Trial
- Comparison of cerebrovascular reactivity recovery following high-intensity interval training and moderate-intensity continuous training.Physiological reports · 2020Trial
- Trial
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Taekwondo Enhances Cognitive Function as a Result of Increased Neurotrophic Growth Factors in Elderly Women.International journal of environmental research and public health · 2019Trial
- The Effects of Taekwondo Training on Peripheral Neuroplasticity-Related Growth Factors, Cerebral Blood Flow Velocity, and Cognitive Functions in Healthy Children: A Randomized Controlled Trial.International journal of environmental research and public health · 2017Trial
- Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease.GeroScience · 2026Article
- Mechanisms regulating cerebral perfusion during running exercise: Influence of foot strike-induced pulsatility oscillations, COThe Journal of physiology · 2026Article
- Physical activity and the aging brain: A narrative review.Journal of health psychology · 2026Review
- Associations among dynamic cerebral autoregulation, baroreflex sensitivity, and carotid distensibility in young healthy adults: insight from endurance training.European journal of applied physiology · 2026Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23 ± 5 years; body mass index (BMI), 26 ± 3 kg m(-2); [Formula: see text], 35 ± 5 ml kg(-1) min(-1)) and 10 older (63 ± 5 years; BMI, 25 ± 3.0 kg m(-2); [Formula: see text], 26 ± 4 ml kg(-1) min(-1)) previously sedentary individuals breathed 5 % CO2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s(-1) (30 and 70 % HRR, respectively) vs. 5 and 4 cm s(-1) (older), P < 0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87 ± 0.76 vs. 2.54 ± 1.12 cm s(-1) mm Hg(-1), P = 0.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.