Trial reportClinical orthopaedics and related research2012
Highly crosslinked polyethylene does not reduce aseptic loosening in cemented THA 10-year findings of a randomized study.
Trial report in Clinical orthopaedics and related research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review.Scientific reports · 2023Pooled it
- Ceramic on Ceramic or Ceramic-on-polyethylene for Total Hip Arthroplasty: A Systemic Review and Meta-analysis of Prospective Randomized Studies.Chinese medical journal · 2015Pooled it
- Do oxidized zirconium femoral heads reduce polyethylene wear in cemented THAs? A blinded randomized clinical trial.Clinical orthopaedics and related research · 2015Trial
- The John Charnley Award: Highly crosslinked polyethylene in total hip arthroplasty decreases long-term wear: a double-blind randomized trial.Clinical orthopaedics and related research · 2015Trial
- Significant functional improvements and radiographic stability following fully cemented total hip arthroplasty in elderly patients: A 2-year prospective study.Journal of orthopaedics · 2025Article
- What is the Long-term Wear of a 5-Mrad Highly Crosslinked Polyethylene Liner? A 14-year RSA Study.Clinical orthopaedics and related research · 2024Article
- Rate of revision and wear penetration in different polyethylene liner compositions in total hip arthroplasty: a Bayesian network meta-analysis.Scientific reports · 2024Article
- Head, acetabular liner composition, and rate of revision and wear in total hip arthroplasty: a Bayesian network meta-analysis.Scientific reports · 2023Article
- How is hip anatomy reconstruction and inlay wear associated up to 10 years after primary THA using ceramic on highly crosslinked polyethylene bearings?BMC musculoskeletal disorders · 2023Article
- Highly cross-linked polyethylene still outperforms conventional polyethylene in THA: 10-year RSA results.Acta orthopaedica · 2021Article
- Highly cross-linked versus conventional polyethylene inserts in total hip arthroplasty, a five-year Roentgen stereophotogrammetric analysis randomised controlled trial.World journal of orthopedics · 2020Article
- Article
- Long-term performance of oxidized zirconium on conventional and highly cross-linked polyethylene in total hip arthroplasty.SICOT-J · 2020Article
- Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-κB and MAPK signaling pathways.Journal of cellular physiology · 2019Article
- Crack initiation from a clinically relevant notch in a highly-crosslinked UHMWPE subjected to static and cyclic loading.Journal of the mechanical behavior of biomedical materials · 2019Article
- A long-term comparative study between two different designs of cemented stems: Distal-cylindrical versus distal-taper.Journal of orthopaedics · 2018Article
- Tanshinone IIA protects against polyethylene particle-induced osteolysis response in a mouse calvarial model.International journal of clinical and experimental pathology · 2018Article
- Polyethylene and highly cross-linked polyethylene for cemented total hip arthroplasty: A comparison of over ten-year clinical and radiographic results.Journal of orthopaedics · 2017Article
- Validation of a new 2-D technique for radiographic wear measurement of cemented, highly cross-linked polyethylene acetabular cups.Medical engineering & physics · 2017Article
- Outcome in design-specific comparisons between highly crosslinked and conventional polyethylene in total hip arthroplasty.Acta orthopaedica · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyethylene (PE) wear particles are believed to cause aseptic loosening and thereby impair function in hip arthroplasty. Highly crosslinked polyethylene (XLPE) has low short- and medium-term wear rates. However, the long-term wear characteristics are unknown and it is unclear whether reduced wear particle burden improves function and survival of cemented hip arthroplasty. QUESTIONS/PURPOSES: We asked whether XLPE wear rates remain low up to 10 years and whether this leads to improved implant fixation, periprosthetic bone quality, and clinical function compared to conventional PE.
methodsWe randomized 60 patients (61 hips) to receive either PE or XLPE cemented cups combined with a cemented stem. At 10 years postoperatively, 51 patients (52 hips) were evaluated for polyethylene wear and component migration estimation by radiostereometry, for radiolucent lines, bone densitometry, and Harris hip and pain scores. Revisions were recorded.
resultsXLPE cups had a lower mean three-dimensional wear rate between 2 and 10 years compared to conventional PE hips: 0.005 mm/year versus 0.056 mm/year. We found no differences in cup migration, bone mineral density, radiolucencies, functional scores, and revision rate. There was a trend toward improved stem fixation in the XLPE group. The overall stem failure rate was comparably high, without influencing wear rate in XLPE hips.
conclusionsXLPE displayed a low wear rate up to 10 years when used in cemented THA, but we found no clear benefits in any other parameters. Further research is needed to determine whether cemented THA designs with XLPE are less prone to stem loosening. LEVEL OF EVIDENCE: Level I, therapeutic study. See the Instructions for Authors for a complete description of levels of evidence.
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