ArticleFamilial cancer2012
Microsatellite instability testing in Korean patients with colorectal cancer.
Article in Familial cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Universal Screening for Lynch Syndrome Compared with Pedigree-Based Screening: 10-Year Experience in a Tertiary Hospital.Cancer research and treatment · 2023Article
- Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer.Annals of surgical treatment and research · 2022Article
- CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.Molecular cancer · 2021Article
- [Clinicopathological features and types of microsatellite instability in 1394 patients with colorectal cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Development and validation of MMR prediction model based on simplified clinicopathological features and serum tumour markers.EBioMedicine · 2020Article
- Differential prognostic impact of CD8British journal of cancer · 2020Article
- Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?Annals of coloproctology · 2017Article
- The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients.BMC cancer · 2017Article
- Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age.Cancer medicine · 2017Article
- Article
- Molecular Testing for Gastrointestinal Cancer.Journal of pathology and translational medicine · 2017Review
- Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers.British journal of cancer · 2016Article
- Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans.Cancer research and treatment · 2016Article
- Comparison between Resectable Helicobacter pylori-Negative and -Positive Gastric Cancers.Gut and liver · 2016Article
- BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis.PloS one · 2016Article
- Clinical and prognostic value of MET gene copy number gain and chromosome 7 polysomy in primary colorectal cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer.Medicine · 2015Observational
- HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value.Virchows Archiv : an international journal of pathology · 2015Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsatellite instability (MSI) testing is useful for identifying patients with hereditary nonpolyposis colorectal cancer and detecting sporadic colorectal cancer that develops through replication error pathways. A pentaplex panel is recommended by the National Cancer Institute for MSI testing, but simplified mononucleotide panels and immunohistochemistry of mismatch repair proteins are widely employed for convenience. This study was to evaluate the MSI status of colorectal cancer in Korean patients. This study included 1,435 patients with colorectal adenocarcinoma subjected to surgical resection. The pentaplex Bethesda panel was used for MSI testing. Seventy nine (5.5 %) carcinomas were classified as MSI-high (MSI-H) and 95 (6.6 %) as MSI-low (MSI-L). BAT-26 and BAT-25 were unstable in 73 and 75 of 79 MSI-H carcinomas, respectively. With the panel comprising these 2 mononucleotide markers, 72 carcinomas were diagnosed as MSI-H, compared to the Bethesda panel data (72/79, 91.1 %). In contrast, BAT-26 or BAT-25 were unstable in only 7 (7.4 %) of the 95 MSI-L tumors. In the panel with 2 dinucleotide markers, D17250 linked to p53 and D2S123 to hMSH2, detection rates were 89.9 % (71/79) for MSI-H and 80.0 % (76/95) for MSI-L carcinomas, compared to the Bethesda panel. Moreover, we compared the frequency of MSI tumor in our patients with those reported previously from Western countries. In conclusion, the frequency of MSI-H appears lower in colorectal cancer patients in Korea. A simplified panel for MSI testing with BAT-26 and BAT-25 seems not effective for the accurate evaluation of MSI status, particularly in MSI-L colorectal carcinomas, in our patients.
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