ArticleJournal of neurology2012
Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint.
Article in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes.The Cochrane database of systematic reviews · 2014Pooled it
- Clinical and cognitive assessment in Friedreich ataxia clinical trials: a review.Frontiers in neurology · 2025Review
- Quantitative Speech Assessment in Ataxia-Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Markers.Cerebellum (London, England) · 2024Review
- Perceptual and Acoustic Analysis of Speech in Spinocerebellar ataxia Type 1.Cerebellum (London, England) · 2024Article
- Sensitive Quantification of Cerebellar Speech Abnormalities Using Deep Learning Models.IEEE access : practical innovations, open solutions · 2024Article
- Home-based biofeedback speech treatment improves dysarthria in repeat-expansion SCAs.Annals of clinical and translational neurology · 2022Article
- A Longitudinal Evaluation of Speech Rate in Primary Progressive Apraxia of Speech.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Speech and Language Disorders in Friedreich Ataxia: Highlights on Phenomenology, Assessment, and Therapy.Cerebellum (London, England) · 2020Review
- Oral mobility reflects rate of progression in advanced Friedreich's ataxia.Annals of clinical and translational neurology · 2019Article
- The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting.Future science OA · 2019Review
- Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice.Cerebellum (London, England) · 2018Review
- Coordination and timing deficits in speech and swallowing in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).Journal of neurology · 2018Article
- Automatic Evaluation of Speech Rhythm Instability and Acceleration in Dysarthrias Associated with Basal Ganglia Dysfunction.Frontiers in bioengineering and biotechnology · 2015Article
- Dysphagia and swallowing-related quality of life in Friedreich ataxia.Journal of neurology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CNS functions that show change across short periods of time are particularly useful clinical endpoints for Friedreich ataxia. This study determined whether there is measurable acoustical change in the dysarthria associated with Friedreich ataxia across yearly intervals. A total of 29 participants diagnosed with Friedreich ataxia were recorded across 4 years at yearly intervals. A repeated measures ANOVA was used to determine which acoustic measures differed across time, and pairwise t tests were used to assess the consistency of the change across the time intervals. The relationship between the identified measures with perceptual severity was assessed with stepwise regression. Significant longitudinal change was observed with four measures that relate to the utterance duration and spectral changes in utterances. The spectral measures consistently detected change across time intervals of two or more years. The four measures combined moderately predicted perceptual severity. Together, the results implicate longitudinal change in speaking rate and utterance duration. Changes in speech associated with Friedreich ataxia can be measured across intervals of 2 years and therefore show rich potential for monitoring disease progression and therapy outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.