Evidence map›Paper›PMID 22669220›Full record

ReviewNature reviews. Microbiology2012

Replication-transcription conflicts in bacteria.

Houra Merrikh, Yan Zhang, Alan D Grossman, Jue D Wang

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed.

  1. Article
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  8. Article
  9. Review
  10. Review
  11. Article
  12. LUMINIDEPENDENS orchestrates global transcriptional repression inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. International journal of molecular sciences · 2025
    Article
  18. Phase variation inMicrobiology spectrum · 2025
    Article
  19. Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Houra MerrikhDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Yan Zhang
Alan D Grossman
Jue D Wang

Funding

Cell Cycle and Sporulation in Bacillis SubtillisR37GM041934 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GROSSMAN, ALAN D · 2009 to 2017
$4.8M
INITITATION OF SPORULATION IN BACILLUS SUBTILISR01GM041934 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GROSSMAN, ALAN D · 1989 to 2007
$2.6M
Control of GTP Homeostasis by (p)ppGppR01GM084003 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, JUE D. · 2009 to 2017
$2.2M
Regulation of DNA replication in B.subtilis by YabAF32GM093408 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MERRIKH, HOURA · 2010 to 2011
$78k
NIGMS NIH HHS F32 GM093408NIGMS NIH HHS GM084003NIGMS NIH HHS GM093408NIGMS NIH HHS R01 GM041934NIGMS NIH HHS R01 GM084003NIGMS NIH HHS R37 GM041934
6 · The paper itself

Abstract

DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries.

Indexed as

BacteriaBacterial ProteinsDNA, BacterialDNA ReplicationGene Expression Regulation, BacterialTranscription, GeneticTranscription Initiation SiteBacterial ProteinsDNA, Bacterial

Identifiers

PMID22669220
PMCPMC3467967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.