Evidence map›Paper›PMID 22668883›Full record

ArticlePreventive medicine2012

Maintenance of reinforcement to address the chronic nature of drug addiction.

Kenneth Silverman, Anthony DeFulio, Sigurdur O Sigurdsson

Open access · greenAbstract read
In one paragraph

Article in Preventive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Evaluation of a Computer-Based Training Program to Teach Adults at Risk for HIV About Pre-Exposure Prophylaxis.AIDS education and prevention : official publication of the International Society for AIDS Education · 2018
    Trial
  4. Trial
  5. Employment-based reinforcement of adherence to oral naltrexone in unemployed injection drug users: 12-month outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Social odor choice buffers drug craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  13. Article
  14. Article
  15. The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  16. Article
  17. Review
  18. The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kenneth SilvermanJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, 5200 Eastern Avenue, Baltimore, MD 21224, USA. ksilverm@jhmi.edu
Anthony DeFulio
Sigurdur O Sigurdsson
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Employment-Based Depot Naltrexone Clinical TrialR01DA019497 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 2005 to 2016
$6.3M
A Bridge to Treatment for Out-of-Treatment Injection Heroin UsersR01DA023864 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 2007 to 2011
$3.2M
Employment-Based Addiction PharmacotherapyR01DA019386 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 2005 to 2009
$3.1M
NIDA NIH HHS R01 DA019386NIDA NIH HHS R01DA019386NIDA NIH HHS R01 DA019497NIDA NIH HHS R01DA019497NIDA NIH HHS R01 DA023864NIDA NIH HHS R01DA023864
6 · The paper itself

Abstract

backgroundDrug addiction can be a chronic problem. Abstinence reinforcement can initiate drug abstinence, but as with other treatments many patients relapse after the intervention ends. Abstinence reinforcement can be maintained to promote long-term drug abstinence, but practical means of implementing long-term abstinence reinforcement are needed.

methodsWe reviewed 8 clinical trials conducted in Baltimore, MD from 1996 through 2010 that evaluated the therapeutic workplace as a vehicle for maintaining reinforcement for the treatment of drug addiction. The therapeutic workplace uses employment-based reinforcement in which employees must provide objective evidence of drug abstinence or medication adherence to work and earn wages.

resultsEmployment-based reinforcement can initiate (3 of 4 studies) and maintain (2 studies) cocaine abstinence in methadone patients, although relapse can occur even after long-term exposure to abstinence reinforcement (1 study). Employment-based reinforcement can also promote abstinence from alcohol in homeless alcohol dependent adults (1 study), and maintain adherence to extended-release naltrexone in opioid dependent adults (2 studies).

conclusionTreatments should seek to promote life-long effects in patients. Therapeutic reinforcement may need to be maintained indefinitely to prevent relapse. Workplaces could be effective vehicles for the maintenance of therapeutic reinforcement contingencies for drug abstinence and adherence to addiction medications.

Indexed as

Medication AdherenceMotivationWorkplaceAnalgesics, OpioidBaltimoreClinical Trials as TopicCocaine-Related DisordersFemaleHumansMaleMethadoneSecondary PreventionSubstance Abuse DetectionAnalgesics, OpioidMethadone

Identifiers

PMID22668883
PMCPMC3437006
OpenAlexW1967135019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.