ReviewJournal of molecular and cellular cardiology2013
Transition metals and mitochondrial metabolism in the heart.
Review in Journal of molecular and cellular cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Associations Between Metal-Metal Interaction and the Risk of Hypertension: A Case-Control Study in Chinese Community-Dwelling Elderly.Cardiovascular toxicology · 2025Article
- Exposure to Multiple Metal(loid)s and Hypertension in Chinese Older Adults.Biological trace element research · 2025Article
- Impact of multi-metal exposure on blood pressure: a mediation analysis through oxidative stress markers in China's Southern Jiangxi Province.BMC public health · 2025Article
- Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities.International journal of molecular sciences · 2024Review
- Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies.Frontiers in pharmacology · 2024Review
- Taurine Protects against the Fatty Liver Hemorrhagic Syndrome in Laying Hens through the Regulation of Mitochondrial Homeostasis.International journal of molecular sciences · 2023Article
- Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China.Frontiers in public health · 2023Article
- Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules.The Journal of biological chemistry · 2021Review
- The association between blood metals and hypertension in the GuLF study.Environmental research · 2021Article
- Airborne metals exposure and risk of hypertension in the Sister Study.Environmental research · 2020Article
- Review
- Modulating effect of tiron on the capability of mitochondrial oxidative phosphorylation in the brain of rats exposed to radiation or manganese toxicity.Environmental science and pollution research international · 2019Article
- Mitochondrial membrane transporters and metabolic switch in heart failure.Heart failure reviews · 2019Review
- Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics.The Journal of cell biology · 2018Article
- Further aspects of Toxoplasma gondii elimination in the presence of metals.Parasitology research · 2018Article
- Editorial: Metal Biology Takes Flight: The Study of Metal Homeostasis and Detoxification in Insects.Frontiers in genetics · 2018Article
- Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway.PeerJ · 2016Article
- Metal-catalyzed protein tyrosine nitration in biological systems.Redox report : communications in free radical research · 2014Review
- Mitochondrial metals as a potential therapeutic target in neurodegeneration.British journal of pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transition metals are essential to many biological processes in almost all organisms from bacteria to humans. Their versatility, which arises from an ability to undergo reduction-oxidation chemistry, enables them to act as critical cofactors of enzymes throughout the cell. Accumulation of metals, however, can also lead to oxidative stress and cellular damage. The importance of metals to both enzymatic reactions and oxidative stress makes them key players in mitochondria. Mitochondria are the primary energy-generating organelles of the cell that produce ATP through a chain of enzymatic complexes that require transition metals, and are highly sensitive to oxidative damage. Moreover, the heart is one of the most mitochondrially-rich tissues in the body, making metals of particular importance to cardiac function. In this review, we focus on the current knowledge about the role of transition metals (specifically iron, copper, and manganese) in mitochondrial metabolism in the heart. This article is part of a Special Issue entitled "Focus on Cardiac Metabolism".
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.