ArticleJournal of molecular and cellular cardiology2012
CXCR4 gene transfer prevents pressure overload induced heart failure.
Article in Journal of molecular and cellular cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Uncovering the Heterogeneity of Cardiac Lin-KIT+ Cells: A scRNA-seq Study on the Identification of Subpopulations.Stem cells (Dayton, Ohio) · 2023Article
- The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death.Biomolecules · 2021Article
- Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure.Circulation. Heart failure · 2020Article
- CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy.International journal of molecular sciences · 2019Article
- Stromal cell-derived factor-1α signals via the endothelium to protect the heart against ischaemia-reperfusion injury.Journal of molecular and cellular cardiology · 2019Article
- Therapeutic strategies utilizing SDF-1α in ischaemic cardiomyopathy.Cardiovascular research · 2018Review
- CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures.Cardiorenal medicine · 2018Observational
- SDF-1 induces TNF-mediated apoptosis in cardiac myocytes.Apoptosis : an international journal on programmed cell death · 2018Article
- CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.Stem cell research · 2017Article
- Exosomes: A Rising Star in Falling Hearts.Frontiers in physiology · 2017Review
- Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl-2, and Caspase-3 in Chronic Heart Failure Rats.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems.Mediators of inflammation · 2016Review
- CXCR4 attenuates cardiomyocytes mitochondrial dysfunction to resist ischaemia-reperfusion injury.Journal of cellular and molecular medicine · 2015Article
- Circulating Stromal Cell-Derived Factor 1α Levels in Heart Failure: A Matter of Proper Sampling.PloS one · 2015Article
- The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury.The Journal of clinical investigation · 2014Article
- Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats.Nutrition research (New York, N.Y.) · 2014Article
- Chemokines and chemokine receptors: update on utility and challenges for the clinician.Surgery · 2014Review
- Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration.Gene therapy · 2014Article
- NFAT signaling in osteoblasts regulates the hematopoietic niche in the bone microenvironment.Clinical & developmental immunology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Stem cell and gene therapies are being pursued as strategies for repairing damaged cardiac tissue following myocardial infarction in an attempt to prevent heart failure. The chemokine receptor-4 (CXCR4) and its ligand, CXCL12, play a critical role in stem cell recruitment post-acute myocardial infarction. Whereas progenitor cell migration via the CXCL12/CXCR4 axis is well characterized, little is known about the molecular mechanisms of CXCR4 mediated modulation of cardiac hypertrophy and failure. We used gene therapy to test the effects of CXCR4 gene delivery on adverse ventricular remodeling due to pressure overload. We assessed the effect of cardiac overexpression of CXCR4 during trans-aortic constriction (TAC) using a cardiotropic adeno-associated viral vector (AAV9) carrying the CXCR4 gene. Cardiac overexpression of CXCR4 in mice with pressure overload prevented ventricular remodeling, preserved capillary density and maintained function as determined by echocardiography and in vivo hemodynamics. In isolated adult rat cardiac myocytes, CXCL12 treatment prevented isoproterenol induced hypertrophy and interrupted the calcineurin/NFAT pathway. Finally, a complex involving the L-type calcium channel, β2-adrenoceptor, and CXCR4 (Cav1.2/β2AR/CXCR4) was identified in healthy cardiac myocytes and was shown to dissociate as a consequence of heart failure. CXCR4 administered to the heart via gene transfer prevents pressure overload induced heart failure. The identification of CXCR4 participation in a Cav1.2-β2AR regulatory complex provides further insight into the mechanism by which CXCR4 modulates calcium homeostasis and chronic pressure overload responses in the cardiac myocyte. Together these results suggest that AAV9.CXCR4 gene therapy is a potential therapeutic approach for congestive heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.