Evidence map›Paper›PMID 22667351›Full record

ReviewChemical research in toxicology2012

Relationships between the renal handling of DMPS and DMSA and the renal handling of mercury.

Rudolfs K Zalups, Christy C Bridges

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical research in toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials.International journal of environmental research and public health · 2023
    Review
  6. Transport and Toxicity of Methylmercury-Cysteine in Cultured BeWo Cells.International journal of molecular sciences · 2021
    Article
  7. Chronic Kidney Disease and Exposure to Nephrotoxic Metals.International journal of molecular sciences · 2017
    Review
  8. Review
  9. Review
  10. The role of chelation in the treatment of arsenic and mercury poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2013
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rudolfs K ZalupsDivision of Basic Medical Sciences, 1550 College Street, Mercer University School of Medicine, Macon, GA 31207, USA. zalups_rk@mercer.edu
Christy C Bridges
Mercer University · US

Funding

TRANSPORT-TOXICITY OF INORGANIC MERCURY IN THE NEPHRONR01ES005980 · NIEHS · MERCER UNIVERSITY MACON · PI ZALUPS, RUDOLFS KARLIS · 1993 to 2006
$1.7M
Proximal Tubular Transport of Mercury and Effects of Reduced Renal MassR15ES019991 · NIEHS · MERCER UNIVERSITY MACON · PI BRIDGES, CHRISTY C · 2011 to 2011
$471k
Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the RenalR03ES015511 · NIEHS · MERCER UNIVERSITY MACON · PI BRIDGES, CHRISTY C · 2007 to 2008
$145k
TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRONR55ES005980 · NIEHS · GEORGIA STATE UNIVERSITY · PI BARFUSS, DELON W · 1992 to 1992
–
NIEHS NIH HHS ES015511NIEHS NIH HHS ES019991NIEHS NIH HHS ES05980NIEHS NIH HHS R01 ES005980NIEHS NIH HHS R03 ES015511NIEHS NIH HHS R15 ES019991
6 · The paper itself

Abstract

Within the body of this review, we provide updates on the mechanisms involved in the renal handling mercury (Hg) and the vicinal dithiol complexing/chelating agents, 2,3-bis(sulfanyl)propane-1-sulfonate (known formerly as 2,3-dimercaptopropane-1-sulfonate, DMPS) and meso-2,3-bis(sulfanyl)succinate (known formerly as meso-2,3-dimercaptosuccinate, DMSA), with a focus on the therapeutic effects of these dithiols following exposure to different chemical forms of Hg. We begin by reviewing briefly some of the chemical properties of Hg, with an emphasis on the high bonding affinity between mercuric ions and reduced sulfur atoms, principally those contained in protein and nonprotein thiols. A discussion is provided on the current body of knowledge pertaining to the handling of various mercuric species within the kidneys, focusing on the primary cellular targets that take up and are affected adversely by these species of Hg, namely, proximal tubular epithelial cells. Subsequently, we provide a brief update on the current knowledge on the handling of DMPS and DMSA in the kidneys. In particular, parallels are drawn between the mechanisms participating in the uptake of various thiol S-conjugates of Hg in proximal tubular cells and mechanisms by which DMPS and DMSA gain entry into these target epithelial cells. Finally, we discuss factors that permit DMPS and DMSA to bind intracellular mercuric ions and mechanisms transporting DMPS and DMSA S-conjugates of Hg out of proximal tubular epithelial cells into the luminal compartment of the nephron, and promoting urinary excretion.

Indexed as

AnimalsChelating AgentsDicarboxylic Acid Transportersgamma-GlutamyltransferaseHumansKidneyMercuryMercury PoisoningOrganic Anion TransportersSuccimerSulfhydryl CompoundsUnithiolChelating AgentsDicarboxylic Acid Transportersgamma-GlutamyltransferaseMercuryOrganic Anion TransportersSuccimerSulfhydryl CompoundsUnithiol

Identifiers

PMID22667351
PMCPMC4640686
OpenAlexW2126884036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.