ArticleJournal of applied oral science : revista FOB
Differential expression of salivary glycoproteins in aggressive and chronic periodontitis.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exploring the Non-Toxic Therapeutic Potential ofBiomedicines · 2025Article
- Article
- Review
- Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva.BMC oral health · 2021Article
- Salivary Immunoglobulin Gene Expression in Patients with Caries.Open access Macedonian journal of medical sciences · 2017Article
- Estimation of levels of salivary mucin, amylase and total protein in gingivitis and chronic periodontitis patients.Journal of clinical and diagnostic research : JCDR · 2014Article
- Oral fluid based biomarkers in periodontal disease: part 1. Saliva.Journal of international oral health : JIOH · 2014Review
- Comparison of salivary levels of mucin and amylase and their relation with clinical parameters obtained from patients with aggressive and chronic periodontal disease.Journal of applied oral science : revista FOBArticle
- Comparative evaluation of mucin and total protein in periodontal disease before and after nonsurgical periodontal therapy.Journal of Indian Society of PeriodontologyArticle
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6 authors.
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Abstract
objectivesThe aim of this study was to compare the pattern of secretion and the expression of mucin glycoprotein-2 (MG2) and lactoferrin in individuals with or without periodontitis. MATERIAL AND
methodsFive individuals with aggressive periodontitis (APG), 5 with generalized chronic periodontitis (CPG) and 5 without periodontitis (CG) were enrolled after informed consent. Non-stimulated and stimulated submandibular and sublingual saliva was collected and samples analyzed by Western blot probed with specific antibodies.
resultsStimulated and non-stimulated salivary flow rates did not differ among groups. Western blot analysis revealed that stimulation led to: an increase in MG2 expression in all groups, and to lactoferrin expression in APG and CPG. In non-stimulated saliva, CG exhibited the highest expression of both glycoproteins. In stimulated saliva, CG exhibited the highest expression of MG2, whereas APG the highest of lactoferrin.
conclusionsThe pattern of secretion of MG2 and lactoferrin in health and disease is complex. Although the present study analyzed samples from a limited number of participants, the reduced expression of MG2 and lactoferrin in APG and CPG under non-stimulated condition, the predominant circumstance of salivary secretion during the day, suggests that these salivary constituents may play a role in the etiopathogenesis of these diseases.
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