ArticleTuberculosis research and treatment2012
The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date.
Article in Tuberculosis research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Diagnostic accuracy of Xpert MTB/RIF for tuberculous meningitis: systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2021Pooled it
- MRI quantitative imaging biomarkers in differentiating brain parenchymal tuberculoma and lung cancer brain metastases.European journal of medical research · 2025Article
- Persistence Pays: Diagnosing Tuberculous Meningitis after 11 Negative Polymerase Chain Reaction Evaluations.Internal medicine (Tokyo, Japan) · 2025Article
- Successful treatment of tuberculous meningitis in an Indian female under hemodialysis therapy.CEN case reports · 2023Article
- Review
- Incidence and outcome of patients suffering from meningitis due to spondylodiscitis.Brain & spine · 2023Article
- Racemose neurocysticercosis simulating tuberculous meningitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Chronic and Subacute Meningitis: Differentiating Neoplastic From Non-Neoplastic Etiologies.The Neurohospitalist · 2018Article
- Performance of nested RT-PCR on CSF for tuberculous meningitis diagnosis in HIV-infected patients.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Observational
- Comparison of DNA Extraction Protocols and Molecular Targets to Diagnose Tuberculous Meningitis.Tuberculosis research and treatment · 2017Article
- Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients.Scientific reports · 2016Article
- Hemiballistic movements in a newly HIV patient.IDCases · 2016Article
- Cerebral hemorrhage due to tuberculosis meningitis: a rare case report and literature review.Oncotarget · 2015Review
- Seizures in an immunocompromised adolescent: a case report.Journal of medical case reports · 2015Article
- Diagnostic Value of T-Cell Interferon-γ Release Assays on Cerebrospinal Fluid for Tuberculous Meningitis.PloS one · 2015Article
- Inflammatory optic neuropathies.Continuum (Minneapolis, Minn.) · 2014Review
- False-positive tuberculous meningitis due to laboratory contamination: importance of a holistic clinical evaluation.BMJ case reports · 2014Article
- Fluorescent quantitative PCR of Mycobacterium tuberculosis for differentiating intestinal tuberculosis from Crohn's disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- The Diagnostic Utility of Bact/ALERT and Nested PCR in the Diagnosis of Tuberculous Meningitis.Journal of clinical and diagnostic research : JCDR · 2013Article
- Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer.Case reports in oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) tuberculosis, particularly tuberculous meningitis (TBM), is the severest form of Mycobacterium tuberculosis (M.Tb) infection, causing death or severe neurological defects in more than half of those affected, in spite of recent advancements in available anti-tuberculosis treatment. The definitive diagnosis of CNS tuberculosis depends upon the detection of M.Tb bacilli in the cerebrospinal fluid (CSF). At present, the diagnosis of CNS tuberculosis remains a complex issue because the most widely used conventional "gold standard" based on bacteriological detection methods, such as direct smear and culture identification, cannot rapidly detect M.Tb in CSF specimens with sufficient sensitivity in the acute phase of TBM. Recently, instead of the conventional "gold standard", the various molecular-based methods including nucleic acid amplification (NAA) assay technique, particularly polymerase chain reaction (PCR) assay, has emerged as a promising new method for the diagnosis of CNS tuberculosis because of its rapidity, sensitivity and specificity. In addition, the innovation of nested PCR assay technique is worthy of note given its contribution to improve the diagnosis of CNS tuberculosis. In this review, an overview of recent progress of the NAA methods, mainly highlighting the PCR assay technique, was presented.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.