ReviewNutrients2012
Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus.
Review in Nutrients, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00610688 (High Prevalence of Rickets and Subclinical Maternal and Childhood Vitamin D Deficiency in the Middle East), which is not on this map. Cited by 61 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Prevalence of Rickets and Subclinical Maternal and Childhood Vitamin D Deficiency in the Middle East: a Randomized Controlled Trial of Prenatal Vitamin D Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Circulating vitamin D and the risk of gestational diabetes: a systematic review and dose-response meta-analysis.Endocrine · 2020Pooled it
- Pooled it
- Vitamin D metabolites across the menstrual cycle: a systematic review.BMC women's health · 2019Pooled it
- Maternal Vitamin D Status Correlates to Leukocyte Antigenic Responses in Breastfeeding Infants.Nutrients · 2022Trial
- Maternal nutrition intervention and maternal complications in 4 districts of Bangladesh: A nested cross-sectional study.PLoS medicine · 2019Trial
- Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy.The Journal of steroid biochemistry and molecular biology · 2017Trial
- Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial.Nutrients · 2017Trial
- Maternal vitamin D status and infant outcomes in rural Vietnam: a prospective cohort study.PloS one · 2014Trial
- Severe Vitamin D Deficiency as a Trigger for Metabolic Seizures in Infancy: A Case Series and a Comprehensive Review of the Literature.Nutrients · 2026Review
- Maternal Vitamin D Status and Its Association with Neonatal Health: Clinical Implications and Influencing Factors.Nutrients · 2025Article
- Association of prenatal vitamin D concentration with the eruption time of the first primary tooth: A prospective cohort study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Harnessing behavioral interventions to enhance micronutrient intake in pregnancy: A comprehensive review.Journal of education and health promotion · 2025Review
- Vitamin D Status in Roma Mothers and Newborns: Socioeconomic Factors and Impact on Neonatal Outcome.Nutrients · 2024Article
- Integrating Endocrine, Genomic, and Extra-Skeletal Benefits of Vitamin D into National and Regional Clinical Guidelines.Nutrients · 2024Review
- Article
- Inadequacy of Vitamin D Does Not Interfere with Body Weight Loss in Women of Reproductive Age after Roux-en-Y Gastric Bypass.Biomedicines · 2022Article
- Vitamin D Status and Potential Therapeutic Options in Critically Ill Patients: A Narrative Review of the Clinical Evidence.Diagnostics (Basel, Switzerland) · 2022Review
- Immunonutrients involved in the regulation of the inflammatory and oxidative processes: implication for gamete competence.Journal of assisted reproduction and genetics · 2022Review
- Influence of maternal socioeconomic deprivation and living environment on newborn bloodspot 25-hydroxyvitamin D levels.Frontiers in endocrinology · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite its discovery a hundred years ago, vitamin D has emerged as one of the most controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism and bone health is undisputed but its role in immune function and long-term health is debated. There are clear indicators from in vitro and animal in vivo studies that point to vitamin D's indisputable role in both innate and adaptive immunity; however, the translation of these findings to clinical practice, including the care of the pregnant woman, has not occurred. Until recently, there has been a paucity of data from randomized controlled trials to establish clear cut beneficial effects of vitamin D supplementation during pregnancy. An overview of vitamin metabolism, states of deficiency, and the results of recent clinical trials conducted in the U.S. are presented with an emphasis on what is known and what questions remain to be answered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.