Trial reportPLoS neglected tropical diseases2012
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
Trial report in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Elucidating the causal mechanisms of Taenia solium transmission in humans, pigs and the environment: A global systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- A qualitative assessment of the context and enabling environment for the control of Taenia solium infections in endemic settings.PLoS neglected tropical diseases · 2021Pooled it
- Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models.PLoS neglected tropical diseases · 2019Pooled it
- Prevalence and risk factors associated with Taenia solium cysticercosis in pigs in Oyam district, Uganda.PLoS neglected tropical diseases · 2025Article
- Confirmation by necropsy of a high prevalence of porcine cysticercosis in a rural district of Madagascar.Parasitology · 2023Article
- Effects of a Digital Health Literacy Intervention on Porcine Cysticercosis Prevalence and Associated Household Practices in Iringa District, Tanzania.Pathogens (Basel, Switzerland) · 2023Article
- Effect of oxfendazole to controlJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Perceptions and acceptability of piloted Taenia solium control and elimination interventions in two endemic communities in eastern Zambia.Transboundary and emerging diseases · 2020Article
- Oxfendazole: a promising agent for the treatment and control of helminth infections in humans.Expert review of anti-infective therapy · 2019Review
- Mathematical model of the life cycle of taenia-cysticercosis: transmission dynamics and chemotherapy (Part 1).Theoretical biology & medical modelling · 2018Article
- Improved methods to capture the total societal benefits of zoonotic disease control: Demonstrating the cost-effectiveness of an integrated control programme for Taenia solium, soil transmitted helminths and classical swine fever in northern Lao PDR.PLoS neglected tropical diseases · 2018Article
- Piloting the effectiveness of pig health education in combination with oxfendazole treatment on prevention and/or control of porcine cysticercosis, gastrointestinal parasites, African swine fever and ectoparasites in Angónia District, Mozambique.Tropical animal health and production · 2018Article
- Preliminary assessment of the computer-based Taenia solium educational program 'The Vicious Worm' on knowledge uptake in primary school students in rural areas in eastern Zambia.Tropical medicine & international health : TM & IH · 2018Article
- Reducing zoonotic and internal parasite burdens in pigs using a pig confinement system.Veterinary world · 2017Article
- Assessing the impact of intervention strategies against Taenia solium cysticercosis using the EPICYST transmission model.Parasites & vectors · 2017Article
- CystiSim - An Agent-Based Model for Taenia solium Transmission and Control.PLoS neglected tropical diseases · 2016Article
- Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa.Parasites & vectors · 2015Article
- Managing neurocysticercosis: challenges and solutions.International journal of general medicine · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were selected and assigned randomly to OFZ treatment or control groups. Fifty-four piglets were treated at 4 months of age (T1), while another 54 piglets were treated at 9 months of age (T2) and these were matched with 108 control pigs from the same litters and raised under the same conditions. Baseline data were collected on the prevalence of porcine cysticercosis using antigen ELISA (Ag-ELISA), as well as knowledge and practices related to Taenia solium transmission based on questionnaire interviews and observations. All animals were followed and re-tested for porcine cysticercosis by Ag-ELISA at 9 and 12 months of age when the study was terminated. Overall prevalence at baseline was 5.1% with no significant difference between groups. At the end of the study, 66.7% of the controls were found positive, whereas 21.4% of the T1 and 9.1% of the T2 pigs were positive, respectively. Incidence rates of porcine cysticercosis were lower in treated pigs as compared to controls. Necropsy of 30 randomly selected animals revealed that viable cysts were present in none (0/8) of T2 pigs, 12.5% (1/8) of T1 pigs and 42.8% (6/14) of control pigs. There was a significant reduction in the risk of T. solium cysticercosis if pigs were treated with OFZ either at 4 months (OR = 0.14; 95% CI: 0.05-0.36) or at 9 months of age (OR = 0.05; 95% CI: 0.02-0.16). Strategic treatment of pigs in endemic areas should be further explored as a means to control T. solium cysticercosis/taeniosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.