ArticlePloS one2012
Regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Article
- Whole genome sequencing analysis of non-O157 Shiga toxin-producingIranian journal of veterinary research · 2024Article
- A bottom-up view of antimicrobial resistance transmission in developing countries.Nature microbiology · 2022Review
- Epidemiology of Plasmids inAntibiotics (Basel, Switzerland) · 2022Article
- Detection of class 1 integron-associated gene cassettes and tetracycline resistance genes inAnnals of medicine and surgery (2012) · 2020Article
- Origin, maintenance and spread of antibiotic resistance genes within plasmids and chromosomes of bloodstream isolates ofMicrobial genomics · 2020Article
- Antimicrobial activities ofMycology · 2020Article
- Antibiotic resistance patterns in human, animal, food and environmental isolates in Ghana: a review.The Pan African medical journal · 2020Review
- Specialization of small non-conjugative plasmids inMicrobial genomics · 2019Article
- Article
- Whole genome sequencing reveals high clonal diversity ofAntimicrobial resistance and infection control · 2018Article
- Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.Antimicrobial agents and chemotherapy · 2017Article
- Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.PloS one · 2017Article
- Classes 1 and 2 integrons in faecal Escherichia coli strains isolated from mother-child pairs in Nigeria.PloS one · 2017Article
- Laboratory systems as an antibacterial resistance containment tool in Africa.African journal of laboratory medicine · 2016Review
- Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis.Frontiers in microbiology · 2016Review
- Emergence of Plasmid-Borne dfrA14 Trimethoprim Resistance Gene in Shigella sonnei.Frontiers in cellular and infection microbiology · 2016Article
- Sulfonamide Resistance Genes (sul) M in Extended Spectrum Beta Lactamase (ESBL) and Non-ESBL Producing Escherichia coli Isolated From Iranian Hospitals.Jundishapur journal of microbiology · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAntimicrobial resistance is a growing international problem. We observed a 50% increase in the prevalence of trimethoprim resistance among fecal Escherichia coli from healthy Nigerian students between 1998 and 2005, a trend to increase that continued in 2009. METHODS AND
findingsA PCR-based screen revealed that 131 (43.1%) of isolates obtained in Nigeria in 2005 and 2009 carried integron-borne dfrA cassettes. In the case of 67 (51.1%) of these isolates, the cassette was a class 1-integron-borne dfrA7 gene, which has been reported at high prevalence from E. coli isolates from other parts of Africa. Complete sequencing of a 27 Kb dfrA7-bearing plasmid from one isolate located the dfrA7 gene within a Tn21-type transposon. The transposon also contained an IS26-derived bla/sul/str element, encoding resistance to β-lactams, sulphonamides and streptomycin, and mercury resistance genes. Although the plasmid backbone was only found in 12 (5.8%) of trimethoprim-resistant isolates, dfrA7 and other transposon-borne genes were detected in 14 (16.3%) and 32 (26.3%) of trimethoprim resistant isolates collected in Nigeria in 2005 and 2009, respectively. Additionally, 37 (19.3%) of trimethoprim-resistant E. coli isolates collected between 2006 and 2008 from Ghana were positive for the dfrA7 and a transposon marker, but only 4 (2.1%) harbored the plasmid backbone.
conclusionsOur data point to transposition as a principal mechanism for disseminating dfrA7 among E. coli from Nigeria and Ghana. On-going intensive use of the affordable broad-spectrum antibacterials is likely to promote selective success of a highly prevalent transposable element in West Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.