ArticlePloS one2012
Adverse metabolic response to regular exercise: is it a rare or common occurrence?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
188 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Association between neuroticism and physical activity: a systematic review and meta-analysis.Frontiers in human neuroscience · 2025Pooled it
- Comparative effects of high-intensity and sprint interval training on cardiorespiratory fitness and body composition: a systematic review with meta-analysis.Frontiers in physiology · 2025Pooled it
- The effects of exercise training on hypertensive older adults: an umbrella meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Pooled it
- Pooled it
- International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines.The journal of nutrition, health & aging · 2021Guideline
- The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.International journal of molecular sciences · 2018Pooled it
- Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2017Pooled it
- Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2017Pooled it
- The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions.Atherosclerosis · 2015Pooled it
- Pooled it
- Impact of resistance and endurance exercise training on femoral artery function: sex differences in humans.The Journal of physiology · 2025Trial
- A Comparative Analysis of High-Intensity Technique-Specific Intervals and Short Sprint Interval Training in Taekwondo Athletes: Effects on Cardiorespiratory Fitness and Anaerobic Power.Journal of sports science & medicine · 2024Trial
- Hypotensive effects of exercise training: are postmenopausal women with hypertension non-responders or responders?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- The Effects of Standardised versus Individualised Aerobic Exercise Prescription on Fitness-Fatness Index in Sedentary Adults: A Randomised Controlled Trial.Journal of sports science & medicine · 2022Trial
- Endurance versus resistance training in treatment of cardiovascular risk factors: A randomized cross-over trial.PloS one · 2022Trial
- miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition.American journal of physiology. Cell physiology · 2021Trial
- Individual cardiovascular responsiveness to work-matched exercise within the moderate- and severe-intensity domains.European journal of applied physiology · 2021Trial
- Low-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes: a randomized parallel group trial.BMJ open diabetes research & care · 2020Trial
- Trial
- Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals.Frontiers in endocrinology · 2020Trial
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundIndividuals differ in the response to regular exercise. Whether there are people who experience adverse changes in cardiovascular and diabetes risk factors has never been addressed. METHODOLOGY/PRINCIPAL
findingsAn adverse response is defined as an exercise-induced change that worsens a risk factor beyond measurement error and expected day-to-day variation. Sixty subjects were measured three times over a period of three weeks, and variation in resting systolic blood pressure (SBP) and in fasting plasma HDL-cholesterol (HDL-C), triglycerides (TG), and insulin (FI) was quantified. The technical error (TE) defined as the within-subject standard deviation derived from these measurements was computed. An adverse response for a given risk factor was defined as a change that was at least two TEs away from no change but in an adverse direction. Thus an adverse response was recorded if an increase reached 10 mm Hg or more for SBP, 0.42 mmol/L or more for TG, or 24 pmol/L or more for FI or if a decrease reached 0.12 mmol/L or more for HDL-C. Completers from six exercise studies were used in the present analysis: Whites (N = 473) and Blacks (N = 250) from the HERITAGE Family Study; Whites and Blacks from DREW (N = 326), from INFLAME (N = 70), and from STRRIDE (N = 303); and Whites from a University of Maryland cohort (N = 160) and from a University of Jyvaskyla study (N = 105), for a total of 1,687 men and women. Using the above definitions, 126 subjects (8.4%) had an adverse change in FI. Numbers of adverse responders reached 12.2% for SBP, 10.4% for TG, and 13.3% for HDL-C. About 7% of participants experienced adverse responses in two or more risk factors. CONCLUSIONS/SIGNIFICANCE: Adverse responses to regular exercise in cardiovascular and diabetes risk factors occur. Identifying the predictors of such unwarranted responses and how to prevent them will provide the foundation for personalized exercise prescription.
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