ArticlePloS one2012
Dynamic gene expression in the human cerebral cortex distinguishes children from adults.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders.Translational psychiatry · 2023Article
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- Pharmacogenomics in Psychiatry Practice: The Value and the Challenges.International journal of molecular sciences · 2022Review
- Learning Through Shared Care : Allomaternal Care Impacts Cognitive Development in Early Infancy in a Western Population.Human nature (Hawthorne, N.Y.) · 2021Article
- Genetic variants related to successful migraine prophylaxis with verapamil.Molecular genetics & genomic medicine · 2021Article
- Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context.Brain, behavior, and immunity · 2021Review
- Emergence of co-expression in gene regulatory networks.PloS one · 2021Article
- From BDNF to reading: Neural activation and phonological processing as multiple mediators.Behavioural brain research · 2021Article
- Evolution and transition of expression trajectory during human brain development.BMC evolutionary biology · 2020Article
- The BDNF ValBehavioural brain research · 2017Article
- Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development.BMC developmental biology · 2016Article
- The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children.PloS one · 2016Article
- News feature: The search for what sets humans apart.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system.Frontiers in cellular neuroscience · 2015Article
- Excess of homozygosity in the major histocompatibility complex in schizophrenia.Human molecular genetics · 2014Article
- Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder.Psychological medicine · 2014Article
- Heritable changes in regional cortical thickness with age.Brain imaging and behavior · 2014Article
- Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.Molecular brain · 2014Article
- Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions.Proceedings. Biological sciences · 2014Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In comparison with other primate species, humans have an extended juvenile period during which the brain is more plastic. In the current study we sought to examine gene expression in the cerebral cortex during development in the context of this adaptive plasticity. We introduce an approach designed to discriminate genes with variable as opposed to uniform patterns of gene expression and found that greater inter-individual variance is observed among children than among adults. For the 337 transcripts that show this pattern, we found a significant overrepresentation of genes annotated to the immune system process (pFDR ~/= 0). Moreover, genes known to be important in neuronal function, such as brain-derived neurotrophic factor (BDNF), are included among the genes more variably expressed in childhood. We propose that the developmental period of heightened childhood neuronal plasticity is characterized by more dynamic patterns of gene expression in the cerebral cortex compared to adulthood when the brain is less plastic. That an overabundance of these genes are annotated to the immune system suggests that the functions of these genes can be thought of not only in the context of antigen processing and presentation, but also in the context of nervous system development.
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