ArticleEvidence-based complementary and alternative medicine : eCAM2012
Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity ofFrontiers in pharmacology · 2021Article
- The Advantages of Connectivity Map Applied in Traditional Chinese Medicine.Frontiers in pharmacology · 2021Review
- Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing.Scientific reports · 2016Article
- Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis.Chinese medicine · 2015Article
- Clinical Applications of Omics Technologies on ZHENG Differentiation Research in Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Article
- Network pharmacology: a new approach for chinese herbal medicine research.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
7 authors.
Funding
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Abstract
ZHENG is the key theory in traditional Chinese medicine (TCM) and it is very important to find the molecular pharmacology of traditional Chinese herbal formulae. One ZHENG is related to many diseases and the herbal formulae are aiming to ZHENG. Therefore, many herbal formulae whose effects on a certain disease have been confirmed might also treat other diseases with the same ZHENG. In this study, the microarrays collected from patients with QiXuXueYu ZHENG (Qi-deficiency and Blood-stasis syndrome) before treatment and after being treated with Fuzheng Huayu Capsule were analyzed by a high-throughput gene microarrays-based drug similarity comparison method, which could find the small molecules which had similar effects with Fuzheng Huayu Capsule. Besides getting the results of anti-inflammatory and anti-fibrosis drugs which embody the known effect of Fuzheng Huayu Capsule, many other small molecules were screened out and could reflect other types of effects of this formula in treating QiXuXueYu ZHENG, including anti-hyperglycemic, anti-hyperlipidemic, hyposenstive effect. Then we integrated this information to display the effect of Fuzheng Huayu Capsule and its potential multiple-target molecular pharmacology. Moreover, through using clinical blood-tested data to verify our prediction, Fuzheng Huayu Capsule was proved to have effects on diabetes and dyslipidemia.
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