ArticleStem cells international2012
Extrafollicular dermal melanocyte stem cells and melanoma.
Article in Stem cells international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies.Frontiers in oncology · 2024Review
- Enrichment of Human Dermal Stem Cells from Primary Cell Cultures through the Elimination of Fibroblasts.Cells · 2023Article
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Identification, Isolation, and Characterization of Melanocyte Precursor Cells in the Human Limbal Stroma.International journal of molecular sciences · 2022Article
- Review
- Protective Effect ofMolecules (Basel, Switzerland) · 2021Article
- The regulatory role of Korean ginseng in skin cells.Journal of ginseng research · 2021Review
- Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration.International journal of molecular sciences · 2020Review
- A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.Nature communications · 2019Article
- Current and Future Perspectives of Stem Cell Therapy in Dermatology.Annals of dermatology · 2017Review
- Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization.Medicinal research reviews · 2017Review
- Phytochemicals for the Management of Melanoma.Mini reviews in medicinal chemistry · 2016Review
- Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.Archives of biochemistry and biophysics · 2014Article
- Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem-cell phenotype.The British journal of dermatology · 2013Article
- Does melanoma begin in a melanocyte stem cell?Journal of skin cancer · 2012Article
- Stem cells in dermatology.Anais brasileiros de dermatologiaReview
- HMB45 protein expression and the immunohistochemical maturation in common blue nevi: a reappraisal.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that extrafollicular dermal melanocyte stem cells (MSCs) persist after birth in the superficial nerve sheath of peripheral nerves and give rise to migratory melanocyte precursors when replacements for epidermal melanocytes are needed on the basal epidermal layer of the skin. If a damaged MSC or melanocyte precursor can be shown to be the primary origin of melanoma, targeted identification and eradication of it by antibody-based therapies will be the best method to treat melanoma and a very effective way to prevent its recurrence. Transcription factors and signaling pathways involved in MSC self-renewal, expansion and differentiation are reviewed. A model is presented to show how the detrimental effects of long-term UVA/UVB radiation on DNA and repair mechanisms in MSCs convert them to melanoma stem cells. Zebrafish have many advantages for investigating the role of MSCs in the development of melanoma. The signaling pathways regulating the development of MSCs in zebrafish are very similar to those found in humans and mice. The ability to easily manipulate the MSC population makes zebrafish an excellent model for studying how damage to MSCs may lead to melanoma.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.