ArticleFrontiers in neural circuits2012
Molecular analysis of ivy cells of the hippocampal CA1 stratum radiatum using spectral identification of immunofluorophores.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus.NeuroImage · 2023Article
- Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus.AIMS neuroscience · 2022Article
- Article
- Morphological diversity and connectivity of hippocampal interneurons.Cell and tissue research · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo.Brain structure & function · 2017Article
- Endogenously Released Neuropeptide Y Suppresses Hippocampal Short-Term Facilitation and Is Impaired by Stress-Induced Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations.Journal of neurovirology · 2016Article
- Neurogliaform cells in cortical circuits.Nature reviews. Neuroscience · 2015Review
- Quantitative assessment of CA1 local circuits: knowledge base for interneuron-pyramidal cell connectivity.Hippocampus · 2013Review
- Cortical NO interneurons: from embryogenesis to functions.Frontiers in neural circuits · 2013Review
- Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits.Frontiers in neural circuits · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal nitric oxide synthase-expressing (nNOS+) GABAergic interneurons are common in hippocampal stratum (str.) radiatum. However, these cells are less well characterized than nNOS+ ivy cells in str. pyramidale or neurogliaform cells (NGC) in str. lacunosum-moleculare. Here we have studied the laminar distribution of the axons and dendrites, and the immunoreactivity of these neurons recorded in rat hippocampal slices. We have used spectral analysis of antibody- or streptavidin-conjugated fluorophores to improve recognition of genuine signals in reactions for molecules such as nNOS and neuropeptide-Y (NPY). We found that most nNOS+ cells with soma in the CA1 area str. radiatum exhibit characteristic properties of ivy cells, and were positive for NPY and negative for reelin. However, laminar distributions of their neurites differ from original characterization of ivy cells with the soma in or close to str. pyramidale. Both their dendrites and axon are mainly in str. radiatum and to a lesser extent in str. oriens, and in addition often extend to str. lacunosum-moleculare. We conclude that ivy cells in str. radiatum may predominantly be feedforward inhibitory interneurons in the CA1 area, and their axonal output delivering GABA, NPY, and NO can influence both the entorhinal cortex innervated and the CA3 innervated zones pre- and post-synaptically. Spectral analysis of fluorophores provides an objective algorithm to analyze signals in immunoreactions for neurochemical markers.
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