ArticleTheScientificWorldJournal2012
Inactivation of the catalytic subunit of cAMP-dependent protein kinase A causes delayed appressorium formation and reduced pathogenicity of Colletotrichum gloeosporioides.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- CgNis1's Impact on Virulence and Stress Response inInternational journal of molecular sciences · 2024Article
- Ethylene Promotes Expression of the Appressorium- and Pathogenicity-Related Genes via GPCR- and MAPK-Dependent Manners inJournal of fungi (Basel, Switzerland) · 2022Article
- Involvement of Protein Kinase CgSat4 in Potassium Uptake, Cation Tolerance, and Full Virulence inFrontiers in plant science · 2022Article
- Article
- Protein Kinase Signaling Pathways in Plant-Frontiers in plant science · 2021Review
- Melatonin Mitigates the Infection ofAntioxidants (Basel, Switzerland) · 2020Article
- Fatty Acid Synthase Beta Dehydratase in the Lipid Biosynthesis Pathway Is Required for Conidiogenesis, Pigmentation and Appressorium Formation inInternational journal of molecular sciences · 2020Article
- The MAPKKK CgMck1 Is Required for Cell Wall Integrity, Appressorium Development, and Pathogenicity inGenes · 2018Article
- The Mitogen-Activated Protein KinaseFrontiers in microbiology · 2017Article
- Isolation and Characterization of the PKAr Gene From a Plant Pathogen, Curvularia lunata.Indian journal of microbiology · 2014Article
- Nitric oxide: an effective weapon of the plant or the pathogen?Molecular plant pathology · 2014Review
- Cgl-SLT2 is required for appressorium formation, sporulation and pathogenicity in Colletotrichum gloeosporioides.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
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5 authors.
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Abstract
The cyclic AMP- (cAMP-) dependent protein kinase A signaling pathway is one of the major signaling pathways responsible for regulation of the morphogenesis and pathogenesis of several pathogenic fungi. To evaluate the role of this pathway in the plant pathogenic fungus, Colletotrichum gloeosporioides, the gene encoding the catalytic subunit of cAMP-dependent protein kinase A, CgPKAC, was cloned, inactivated, and the mutant was analyzed. Analysis of the Cgpkac mutant generated via gene replacement showed that the mutants were able to form appressoria; however, their formation was delayed compared to the wild type. In addition, the mutant conidia underwent bipolar germination after appressoria formation, but no appressoria were generated from the second germ tube. The mutants also showed reduced ability to adhere to a hydrophobic surface and to degrade lipids localized in the appressoria. Based on the number of lesions produced during a pathogenicity test, the mutant's ability to cause disease in healthy mango fruits was reduced, which may be due to failure to penetrate into the fruit. These findings indicate that cAMP-dependent protein kinase A has an important role in regulating morphogenesis and is required for pathogenicity of C. gloeosporioides.
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