ReviewJournal of biomedicine & biotechnology2012
Cytokines and VEGF induction in orthodontic movement in animal models.
Review in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 67 citations in OpenAlex.
- Micro-Raman spectroscopy for monitoring changes in periodontal ligaments and gingival crevicular fluid.Sensors (Basel, Switzerland) · 2014Trial
- DMXAA accelerates orthodontic tooth movement via macrophage-mediated Rab13-enriched extracellular vesicle release and chemokine secretion.Progress in orthodontics · 2026Article
- The Hypoxostat Model: A Conceptual Framework Linking Hypoxia, Oxidative Stress and Periodontal Breakdown Under Orthodontic Load.Antioxidants (Basel, Switzerland) · 2026Article
- Force-Dependent Presence of Senescent Cells Expressing Vascular Endothelial Growth Factor During Orthodontic Tooth Movement.Biology · 2026Article
- Determining the salivary levels of Transforming Growth Factor Beta 1 (TGF-β1) and Vascular Endothelial Growth Factor (VEGF) during the three stages of orthodontic treatment in patients in Mangaluru: A prospective study.Journal of orthodontic science · 2026Article
- The effects of systemic and sustained hypoxia on orthodontic tooth movement in rats.Scientific reports · 2025Article
- Effects of coenzyme QClinical oral investigations · 2024Article
- Influence of Different Orthodontic Brackets on Cytokine and Cortisol Profile.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Administration of a VEGFR‑2-specific MRI contrast agent to assess orthodontic tooth movement : A pilot study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2022Article
- An Evaluation of Different 3D Cultivation Models on Expression Profiles of Human Periodontal Ligament Fibroblasts with Compressive Strain.International journal of molecular sciences · 2022Article
- SMAD 3, Integrin and VEGF Expression in a Periodontal Ligament During Orthodontic Tooth Movement Induced by Hyperbaric Oxygen Therapy andClinical, cosmetic and investigational dentistry · 2022Article
- Using Salivary MMP-9 to Successfully Quantify Periodontal Inflammation during Orthodontic Treatment.Journal of clinical medicine · 2021Article
- Monitoring Salivary Levels of Interleukin 1 Beta (IL-1Mediators of inflammation · 2021Article
- Recombinant human insulin-like growth factor-1 promotes osteoclast formation and accelerates orthodontic tooth movement in rats.Journal of applied oral science : revista FOB · 2021Article
- Role and Regulation of Mechanotransductive HIF-1α Stabilisation in Periodontal Ligament Fibroblasts.International journal of molecular sciences · 2020Article
- Effects of sodium chloride on the gene expression profile of periodontal ligament fibroblasts during tensile strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2020Article
- Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study.Journal of functional morphology and kinesiology · 2020Article
- Immunorthodontics: in vivo gene expression of orthodontic tooth movement.Scientific reports · 2020Article
- Asperosaponin VI Injection Enhances Orthodontic Tooth Movement in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontics is a branch of dentistry that aims at the resolution of dental malocclusions. The specialist carries out the treatment using intraoral or extraoral orthodontic appliances that require forces of a given load level to obtain a tooth movement in a certain direction in dental arches. Orthodontic tooth movement is dependent on efficient remodeling of periodontal ligament and alveolar bone, correlated with several biological and mechanical responses of the tissues surrounding the teeth. A periodontal ligament placed under pressure will result in bone resorption whereas a periodontal ligament under tension results in bone formation. In the primary stage of the application of orthodontic forces, an acute inflammation occurs in periodontium. Several proinflammatory cytokines are produced by immune-competent cells migrating by means of dilated capillaries. In this paper we summarize, also through the utilization of animal models, the role of some of these molecules, namely, interleukin-1β and vascular endothelial growth factor, that are some proliferation markers of osteoclasts and osteoblasts, and the macrophage colony stimulating factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.