ArticleMolecular vision2012
Glutathione S-transferases polymorphisms confer susceptibility to senile cortical cataract in the Han Chinese population.
Article in Molecular vision, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis?BMC ophthalmology · 2015Pooled it
- Modulatory role of GSTT1 and GSTM1 in Punjabi agricultural workers exposed to pesticides.Environmental science and pollution research international · 2018Article
- Allelic interaction effects of DNA damage and repair genes on the predisposition to age-related cataract.PloS one · 2018Article
- An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract.Journal of ophthalmology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to examine whether glutathione S-transferase (GST) polymorphisms were associated with a susceptibility to age-related cortical cataract (cortical ARC) in the Han Chinese population.
methodsGlutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) gene polymorphisms were genotyped in 422 Han Chinese patients with age-related cortical cataract, and in 312 age, sex, and ethnically matched healthy controls, using a multiplex polymerase chain reaction.
resultsThe results showed that the GSTM1 positive genotype had an increased risk of developing cortical ARC (p=0.0002, odds ratio [OR] 1.74, 95% CI 1.30 to 2.34). There was a statistically significant association between the GSTM1 positive genotype and the risk of cataract development in both female and male groups (p=0.026, OR 1.58, 95% CI 1.05 to 2.36; p=0. 002, OR 1.97, 95% CI 1.27 to 3.04, respectively). A combination of GSTM1 positive and GSTT1 null genotypes was associated with the risk of developing age-related cortical cataract (p=0.002, OR 2.19, 95% CI 1.33 to 3.60). The results revealed that the GSTM1 positive genotype was significantly higher in the smoker patients group as compared to the non-smoker patients group (p=0. 016, OR 1.62, 95% CI 1.09 to 2.39). Logistic regression analysis revealed that smoking may be a risk factor for the development of ARC (r=0.120, p=0.013).
conclusionsOur study suggests that the GSTM1 positive genotype and a combination of GSTM1 positive and GSTT1 null genotypes may be associated with a susceptibility to age-related cortical cataract in the Han Chinese population. The current study indicates that smoking may be an important factor in the development of cortical ARC.
Indexed as
Identifiers
22665971PMC3365129W1594724239What OpenQuestion holds
Registered trials
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