Evidence map›Paper›PMID 22665791›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2012

Bioinspired nanofibers support chondrogenesis for articular cartilage repair.

Jeannine M Coburn, Matthew Gibson, Sean Monagle, Zachary Patterson, Jennifer H Elisseeff

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 218 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jeannine M CoburnTranslational Tissue Engineering Center, Wilmer Eye Institute, and Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21287, USA.
Matthew Gibson
Sean Monagle
Zachary Patterson
Jennifer H Elisseeff
Johns Hopkins University · US

Funding

Engineering and Integration of Osteochondral TissueR01EB005517 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2005 to 2008
$1.1M
Fibrous-Hydrogel Composites for Cartilage Repair in an Osteoarthritic EnvironmentF30AG034807 · NIA · JOHNS HOPKINS UNIVERSITY · PI GIBSON, MATTHEW AVERY · 2010 to 2013
$141k
Chondroitin sulfate-fiber hydrogels for cartilage tissue engineeringF31AG033999 · NIA · JOHNS HOPKINS UNIVERSITY · PI COBURN, JEANNINE · 2009 to 2012
$102k
NIA NIH HHS F30 AG 034807NIA NIH HHS F30 AG034807NIA NIH HHS F31 AG 033999NIA NIH HHS F31 AG033999NIBIB NIH HHS R01 EB005517NIBIB NIH HHS R01 EB 05517
6 · The paper itself

Abstract

Articular cartilage repair remains a significant and growing clinical challenge with the aging population. The native extracellular matrix (ECM) of articular cartilage is a 3D structure composed of proteinaceous fibers and a hydrogel ground substance that together provide the physical and biological cues to instruct cell behavior. Here we present fibrous scaffolds composed of poly(vinyl alcohol) and the biological cue chondroitin sulfate with fiber dimensions on the nanoscale for application to articular cartilage repair. The unique, low-density nature of the described nanofiber scaffolds allows for immediate cell infiltration for optimal tissue repair. The capacity for the scaffolds to facilitate cartilage-like tissue formation was evaluated in vitro. Compared with pellet cultures, the nanofiber scaffolds enhance chondrogenic differentiation of mesenchymal stems cells as indicated by increased ECM production and cartilage specific gene expression while also permitting cell proliferation. When implanted into rat osteochondral defects, acellular nanofiber scaffolds supported enhanced chondrogenesis marked by proteoglycan production minimally apparent in defects left empty. Furthermore, inclusion of chondroitin sulfate into the fibers enhanced cartilage-specific type II collagen synthesis in vitro and in vivo. By mimicking physical and biological cues of native ECM, the nanofiber scaffolds enhanced cartilaginous tissue formation, suggesting their potential utility for articular cartilage repair.

Indexed as

ChondrogenesisNanofibersAnimalsCartilage, ArticularExtracellular MatrixGoatsMaleRatsRats, Sprague-DawleyTissue Engineering

Identifiers

PMID22665791
PMCPMC3382486
OpenAlexW2103589970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.