ArticleProceedings of the National Academy of Sciences of the United States of America2012
Reciprocal uniparental disomy in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Comparative functional genomics ofMicrobiology spectrum · 2026Article
- Towards a unified model of aneuploid karyotype dynamics.PLoS genetics · 2026Article
- High-throughput mapping of spontaneous mitotic crossover and genome instability events with sci-L3-Strand-seq.Nucleic acids research · 2026Article
- A tale of two serines: the effects of histone H2A mutations S122A and S129A on chromosome nondisjunction in Saccharomyces cerevisiae.Genetics · 2025Article
- Nonlethal Furfural Exposure Causes Genomic Alterations and Adaptability Evolution in Saccharomyces cerevisiae.Microbiology spectrum · 2023Article
- Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements.PLoS genetics · 2023Article
- Bursts of Genomic Instability Potentiate Phenotypic and Genomic Diversification inFrontiers in genetics · 2022Article
- Meiotic Genes and DNA Double Strand Break Repair in Cancer.Frontiers in genetics · 2022Review
- A mapping platform for mitotic crossover by single-cell multi-omics.Methods in enzymology · 2021Article
- Punctuated Aneuploidization of the Budding Yeast Genome.Genetics · 2020Article
- Plasticity of Mitochondrial DNA Inheritance and its Impact on Nuclear Gene Transcription in Yeast Hybrids.Microorganisms · 2020Article
- Article
- Controlled Reduction of Genomic Heterozygosity in an Industrial Yeast Strain Reveals Wide Cryptic Phenotypic Variation.Frontiers in genetics · 2019Article
- Review
- Increased LOH due to Defective Sister Chromatid Cohesion Is due Primarily to Chromosomal Aneuploidy and not Recombination.G3 (Bethesda, Md.) · 2017Article
- Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.Nature · 2017Article
- Article
- Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The 2013 Thomas Hunt Morgan Medal: Thomas Douglas Petes.Genetics · 2013Article
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2 authors.
Funding
Abstract
In the diploid cells of most organisms, including humans, each chromosome is usually distinguishable from its partner homolog by multiple single-nucleotide polymorphisms. One common type of genetic alteration observed in tumor cells is uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent, resulting in loss of heterozygosity for all single-nucleotide polymorphisms while maintaining diploidy. Somatic UPD events are usually explained as reflecting two consecutive nondisjunction events. Here we report a previously undescribed mode of chromosome segregation in Saccharomyces cerevisiae in which one cell division produces daughter cells with reciprocal UPD for the same pair of chromosomes without an aneuploid intermediate. One pair of sister chromatids is segregated into one daughter cell and the other pair is segregated into the other daughter cell, mimicking a meiotic chromosome segregation pattern. We term this process "reciprocal uniparental disomy."
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