Evidence map›Paper›PMID 22665609›Full record

ArticleThe American journal of tropical medicine and hygiene2012

An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America.

Teresa C F Assumpção, Donald P Eaton, Van M Pham, Ivo M B Francischetti, Valéria Aoki, Gunter Hans-Filho, Evandro A Rivitti, Jesus G Valenzuela, Luis A Diaz, José M C Ribeiro

Open access · hybridAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Interaction ofMicroorganisms · 2024
    Review
  2. Article
  3. An Integrative Sialomic Analysis Reveals Molecules FromFrontiers in cellular and infection microbiology · 2021
    Article
  4. Article
  5. Proteomic Mapping of Multifunctional Complexes Within Triatomine Saliva.Frontiers in cellular and infection microbiology · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Teresa C F AssumpçãoLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA. assumpcaot@niaid.nih.gov
Donald P Eaton
Van M Pham
Ivo M B Francischetti
Valéria Aoki
Gunter Hans-Filho
Evandro A Rivitti
Jesus G Valenzuela
Luis A Diaz
José M C Ribeiro
National Cancer Institute · USUniversidade de São Paulo · BRNational Institute of Allergy and Infectious Diseases · USUniversidade Federal de Mato Grosso do Sul · BRUniversity of North Carolina at Chapel Hill · USWildlife Conservation Society United Kingdom · GB

Funding

Molecular approaches to understand vector-host and vector-pathogen interactionsZIAAI000932 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI VALENZUELA, JESUS · 2009 to 2025
$23.1M
Vector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8M
ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSR01AR032599 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIAZ, LUIS A. · 1987 to 2017
$5.2M
PEMPHIGUS AND PEMPHIGOIDR01AR032081 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIAZ, LUIS A. · 1986 to 2011
$3.3M
Intramural NIH HHSNIAMS NIH HHS R01 AR032081NIAMS NIH HHS R01 AR032599NIAMS NIH HHS R01-AR32081NIAMS NIH HHS R01-AR32599
6 · The paper itself

Abstract

Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature.

Indexed as

TranscriptomeAmino Acid SequenceAnimalsAutoimmune DiseasesBrazilComputational BiologyGene LibraryInsect ProteinsInsect VectorsMolecular Sequence DataMultigene FamilyPemphigusSalivary GlandsSequence Analysis, DNATriatomaInsect Proteins

Identifiers

PMID22665609
PMCPMC3366513
OpenAlexW2104807472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.