ArticleThe American journal of tropical medicine and hygiene2012
Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort study.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta-Analysis.Maternal & child nutrition · 2025Pooled it
- Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta-Analysis.Ethiopian journal of health sciences · 2022Pooled it
- Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low-resource setting.American journal of hematology · 2017Trial
- Sickle cell disease and increased adverse maternal and perinatal outcomes in different genotypes.Hematology, transfusion and cell therapy · 2024Article
- PREGNANCY OUTCOMES IN WOMEN WITH SICKLE CELL DISEASE AT A TERTIARY HOSPITAL IN NIGERIA: A FIVE-YEAR RETROSPECTIVE STUDY.Annals of Ibadan postgraduate medicine · 2024Article
- Pregnancy Outcomes Among Women With Sickle Cell Disease in Bahrain: A Case-Control Study.Cureus · 2024Article
- Impact and burden of sickle cell disease in critically ill obstetric patients in a high dependency unit in Sierra Leone-a registry based evaluation.BMC pregnancy and childbirth · 2023Article
- Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission.The Lancet. Haematology · 2023Review
- Article
- Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Review
- Sustainability of low maternal mortality in pregnant women with SCD in a low-resource setting.Blood advances · 2022Article
- Sickle cell anaemia in vaso-occlusive crisis and acute fatty liver of pregnancy: a case report.Ghana medical journal · 2020Article
- Article
- Sickle Cell Education: A Survey of Antenatal Healthcare Givers.The American journal of tropical medicine and hygiene · 2019Article
- Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low-resource setting.American journal of hematology · 2019Article
- A case series describing causes of death in pregnant women with sickle cell disease in a low-resource setting.American journal of hematology · 2018Article
- Knowledge insufficient: the management of haemoglobin SC disease.British journal of haematology · 2017Review
- Prevalence of Caesarean sections in Enugu, southeast Nigeria: Analysis of data from the Healthy Beginning Initiative.PloS one · 2017Article
- Heme-mediated apoptosis and fusion damage in BeWo trophoblast cells.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal and fetal mortality. This study determines pregnancy outcomes among women with SCD delivering at Korle-Bu Teaching Hospital, Accra, Ghana. Nine hundred sixty (960) medical records of pregnant women (131 HbSS, 112 HbSC, and 717 comparison group) from 2007 to 2008 were reviewed. The HbSS women were at increased risk of eclampsia (adjusted odds ratio [AOR] = 10.56, 95% confidence interval [CI] = 3.60-30.96, P < 0.001), intrauterine growth restriction (AOR = 4.00, 95% CI = 1.38-11.64, P = 0.011), and placenta previa (AOR = 22.03, 95% CI = 9.87-49.14, P < 0.001) compared with the comparison group. The HbSC women had increased risk for intrauterine fetal death (AOR = 3.38, 95% CI = 1.15-9.96, P = 0.027) and decreased risk of delivering low birth weight babies (AOR = 0.21, 95% CI = 0.06-0.73, P = 0.014). Women with SCD in Ghana are at a greater risk of morbidity and mortality in pregnancy compared with women without hemoglobinopathies. Improved maternal and fetal outcomes in Ghanaian women with SCD can be achieved through effective intervention by health care providers with thorough knowledge about predisposing factors toward adverse outcomes.
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