Evidence map›Paper›PMID 22665535›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012

Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.

Joann L Ater, Tianni Zhou, Emiko Holmes, Claire M Mazewski, Timothy N Booth, David R Freyer, Ken H Lazarus, Roger J Packer, Michael Prados, Richard Sposto and 3 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00002944 (Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old), which is not on this map. Cited by 216 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00002944 phase3completednot on this map

Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old

TypeinterventionalSponsorChildren's Oncology GroupRan1997 to 2012Enrolled428ConditionsBrain Tumors, Central Nervous System TumorsArmscarboplatin, lomustine, procarbazine hydrochloride, thioguanine, vincristine sulfate
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 3 syntheses or guidelines pooled it, 430 citations in OpenAlex.

  1. Pooled it
  2. Pediatric low-grade brainstem glioma: a review of current diagnosis and treatment paradigms in the molecular era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  3. Pooled it
  4. Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Trial
  5. Trial
  6. FDA Approval Summary: Dabrafenib in Combination with Trametinib for BRAFV600E Mutation-Positive Low-Grade Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Joann L AterDivision of Pediatrics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. jater@mdanderson.org
Tianni Zhou
Emiko Holmes
Claire M Mazewski
Timothy N Booth
David R Freyer
Ken H Lazarus
Roger J Packer
Michael Prados
Richard Sposto
Gilbert Vezina
Jeffrey H Wisoff
Ian F Pollack
Children's Oncology Group · US

Funding

COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA98543
6 · The paper itself

Abstract

PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is not possible can threaten both function and life. The purpose of this study was to compare two chemotherapy regimens for LGGs in children younger than age 10 years for whom radiotherapy was felt by the practitioner to pose a high risk of neurodevelopmental injury. PATIENTS AND METHODS Previously untreated children younger than age 10 years with progressive or residual LGGs were eligible. Children were randomly assigned to receive carboplatin and vincristine (CV) or thioguanine, procarbazine, lomustine, and vincristine (TPCV). Children with neurofibromatosis are reported separately. Results Of 274 randomly assigned patients who met eligibility requirements, 137 received CV and 137 received TPCV. The 5-year event-free survival (EFS) and overall survival (OS) rates for all eligible patients were 45% ± 3.2% and 86% ± 2.2%, respectively. The 5-year EFS rates were 39% ± 4% for CV and 52% ± 5% for TPCV (stratified log-rank test P = .10; cure model analysis P = .007). On multivariate analysis, factors independently predictive of worse EFS and OS were younger age and tumor size greater than 3 cm(2). Tumor location in the thalamus was also associated with poor OS. CONCLUSION The difference in EFS between the regimens did not reach significance on the basis of the stratified log-rank test. The 5-year EFS was higher for TPCV on the basis of the cure model analysis. Differences in toxicity may influence physician choice of regimens.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBrain NeoplasmsCarboplatinCentral Nervous System NeoplasmsChildChild, PreschoolDrug Administration ScheduleFemaleGliomaHumansInfantLomustineMaleMultivariate AnalysisProcarbazinePrognosisCarboplatinLomustineProcarbazineThioguanineVincristine

Identifiers

PMID22665535
PMCPMC3413276
OpenAlexW2106689678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.