ArticleThe Journal of biological chemistry2012
The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Noncanonical inheritance of phenotypic information by protein amyloids.Nature cell biology · 2024Article
- Identification ofMolecules (Basel, Switzerland) · 2022Article
- Cottonseed extracts regulate gene expression in human colon cancer cells.Scientific reports · 2022Article
- ZFAND5 Is an Independent Prognostic Biomarker of Perihilar Cholangiocarcinoma.Frontiers in oncology · 2022Article
- Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells.Scientific reports · 2021Article
- AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.Nature communications · 2020Article
- Tristetraprolin Regulates TFrontiers in immunology · 2020Article
- Article
- Effect of adalimumab on the expression of genes encoding TNF-α signal paths in skin fibroblastsPostepy dermatologii i alergologii · 2018Article
- Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism.BMC biology · 2015Article
- Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages.BMC genomics · 2014Article
- Functional genomic assessment of phosgene-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2013Article
- LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP.Cellular signalling · 2013Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
AU-rich elements (AREs) in the 3'-UTR of unstable transcripts play a vital role in the regulation of many inflammatory mediators. To identify novel ARE-dependent gene regulators, we screened a human leukocyte cDNA library for candidates that enhanced the activity of a luciferase reporter bearing the ARE sequence from TNF (ARE(TNF)). Among 171 hits, we focused on Zfand5 (zinc finger, AN1-type domain 5), a 23-kDa protein containing two zinc finger domains. Zfand5 expression was induced in macrophages in response to IFNγ and Toll-like receptor ligands. Knockdown of Zfand5 in macrophages decreased expression of ARE class II transcripts TNF and COX2, whereas overexpression stabilized TNF mRNA by suppressing deadenylation. Zfand5 specifically bound to ARE(TNF) mRNA and competed with tristetraprolin, a protein known to bind and destabilize class II ARE-containing RNAs. Truncation studies indicated that both zinc fingers of Zfand5 contributed to its mRNA-stabilizing function. These findings add Zfand5 to the growing list of RNA-binding proteins and suggest that Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding.
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