ArticleGenome research2012
Maintaining replication origins in the face of genomic change.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- pSB3, a member of the 2-micron family of plasmids, replicates and is efficiently partitioned in multiple budding yeast species.G3 (Bethesda, Md.) · 2026Article
- Conservation of a DNA Replication Motif among Phylogenetically Distant Budding Yeast Species.Genome biology and evolution · 2021Article
- Article
- DNA copy-number measurement of genome replication dynamics by high-throughput sequencing: the sort-seq, sync-seq and MFA-seq family.Nature protocols · 2020Article
- The evolution of the temporal program of genome replication.Nature communications · 2018Article
- Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae.Applied and environmental microbiology · 2018Article
- DNA replication timing influences gene expression level.The Journal of cell biology · 2017Article
- Differential paralog divergence modulates genome evolution across yeast species.PLoS genetics · 2017Article
- Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe.Genome biology · 2015Article
- Genome-wide replication landscape of Candida glabrata.BMC biology · 2015Article
- Association between the dynamics of multiple replication origins and the evolution of multireplicon genome architecture in haloarchaea.Genome biology and evolution · 2014Article
- Article
- An autonomously replicating sequence for use in a wide range of budding yeasts.FEMS yeast research · 2014Article
- GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.PLoS genetics · 2014Article
- Analysis of ssDNA gaps and DSBs in genetically unstable yeast cultures.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The dynamics of genome replication using deep sequencing.Nucleic acids research · 2014Article
- Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts.Nucleic acids research · 2013Article
- DNA replication timing.Cold Spring Harbor perspectives in biology · 2013Review
- High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.Genome research · 2013Article
- A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Origins of replication present a paradox to evolutionary biologists. As a collection, they are absolutely essential genomic features, but individually are highly redundant and nonessential. It is therefore difficult to predict to what extent and in what regard origins are conserved over evolutionary time. Here, through a comparative genomic analysis of replication origins and chromosomal replication patterns in the budding yeasts Saccharomyces cerevisiae and Lachancea waltii, we assess to what extent replication origins survived genomic change produced from 150 million years of evolution. We find that L. waltii origins exhibit a core consensus sequence and nucleosome occupancy pattern highly similar to those of S. cerevisiae origins. We further observe that the overall progression of chromosomal replication is similar between L. waltii and S. cerevisiae. Nevertheless, few origins show evidence of being conserved in location between the two species. Among the conserved origins are those surrounding centromeres and adjacent to histone genes, suggesting that proximity to an origin may be important for their regulation. We conclude that, over evolutionary time, origins maintain sequence, structure, and regulation, but are continually being created and destroyed, with the result that their locations are generally not conserved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.