ArticlePediatrics2012
Preeclampsia and retinopathy of prematurity in preterm births.
Article in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Association of Gestational Hypertensive Disorders with Retinopathy of prematurity: A Systematic Review and Meta-analysis.Scientific reports · 2016Pooled it
- Recombinant human erythropoietin improves neurological outcomes in very preterm infants.Annals of neurology · 2016Trial
- Clinical Characteristics and Predictive Features of Neonates With Treatment-Needed Retinopathy of Prematurity: A Retrospective Cohort Study.Health science reports · 2025Article
- Association of hypertensive disorders of pregnancy and gestational diabetes mellitus with developing severe retinopathy of prematurity.International journal of retina and vitreous · 2025Article
- Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study.American journal of perinatology · 2024Article
- A review on retinopathy of prematurity.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Review
- Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine Model.Pediatric research · 2023Article
- Correlation between hypertensive retinopathy and fetal outcomes in patients with preeclampsia in a tertiary care hospital: A prospective cohort study.Indian journal of ophthalmology · 2023Article
- Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023Review
- Forced expiratory flows and diffusion capacity in infants born from mothers with pre-eclampsia.Pediatric pulmonology · 2022Article
- Comparison of Retinopathy of Prematurity Incidence in Preterm Infants of Mothers with Preeclampsia and Infants of Healthy Mothers.Journal of obstetrics and gynaecology of India · 2022Article
- Neonatal outcomes of twins <29 weeks gestation of mothers with hypertensive disorders of pregnancy.Pediatric research · 2022Article
- Refining evidence-based retinopathy of prematurity screening guidelines: The SCREENROP study.Paediatrics & child health · 2020Article
- Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions.Exploration of medicine · 2020Article
- The Serine Protease HTRA-1 Is a Biomarker for ROP and Mediates Retinal Neovascularization.Frontiers in molecular neuroscience · 2020Article
- Pre-eclampsia: pathogenesis, novel diagnostics and therapies.Nature reviews. Nephrology · 2019Review
- The curse of the perinatal epidemiologist: inferring causation amidst selection.Current epidemiology reports · 2018Article
- Causal inference in studies of preterm babies: a simulation study.BJOG : an international journal of obstetrics and gynaecology · 2018Article
- Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe relationship between gestational hypertension, preeclampsia, and the risk of retinopathy of prematurity (ROP) remains unclear. Thus, we used a large cohort database to study the influence of maternal gestational hypertension and preeclampsia on the occurrence of ROP in preterm infants.
methodsWe used data from a previous retrospective cohort study that includes 25,473 eligible preterm neonates. We examined the association between gestational hypertension, preeclampsia, and ROP while controlling for potential confounders by multiple logistic regression analysis.
resultsOf the 8758 early preterm infants (gestational age <34 weeks), 1024 (11.69%) had ROP, while of the 16,715 late preterm infants, only 29 (0.17%) had ROP. After adjusting for confounders, preeclampsia was associated with a significantly reduced risk of ROP (adjusted odds ratio [aOR], 0.65; 95% confidence interval [CI], 0.49-0.86 for early preterm birth; aOR, 0.10; 95% CI, 0.01-0.93 for late preterm birth; aOR, 0.66; 95% CI, 0.50-0.87 for all preterm births). Gestational hypertension was not significantly associated with ROP at early or late preterm births.
conclusionsPreeclampsia, but not gestational hypertension, was associated with a reduced risk of ROP in preterm births.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.