Evidence map›Paper›PMID 22665238›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2012

Analytical methods for disease association studies with immunogenetic data.

Jill A Hollenbach, Steven J Mack, Glenys Thomson, Pierre-Antoine Gourraud

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  7. Cells · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jill A HollenbachCenter for Genetics, Children's Hospital and Research Center Oakland, Oakland, CA, USA. jhollenbach@chori.org
Steven J Mack
Glenys Thomson
Pierre-Antoine Gourraud

Funding

The Role of HLA and KIR in Rheumatoid Arthritis and Crohn's DiseaseU01AI067068 · NIAID · STANFORD UNIVERSITY · PI ERLICH, HENRY A, TRACHTENBERG, ELIZABETH A · 2005 to 2014
$10.9M
Systemic Lupus Erythematosus and Ulcerative Colitis StudyU19AI067152 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLARESKOG, LARS · 2005 to 2009
$10.1M
The genetic basis of type 1 diabetes autoimmunity in African AmericansR01DK061722 · NIDDK · CHILDREN'S HOSPITAL &RES CTR AT OAKLAND · PI NOBLE, JANELLE A · 2003 to 2013
$3.5M
NIAID NIH HHS U01 AI067068NIAID NIH HHS U01AI067068NIAID NIH HHS U19 AI067152NIDDK NIH HHS 1R01DK061722NIDDK NIH HHS R01 DK061722
6 · The paper itself

Abstract

Disease association studies involving highly polymorphic immunogenetic data may involve analyses at one or many units of analysis, including amino acid, allele, genotype and haplotype levels, as well as consideration of gene-gene or gene-environment interactions. The selection of the appropriate statistical tests is critical and will be dependent on the nature of the dataset (e.g., case-control vs. family data) as well as the specific research hypotheses being tested. This paper describes the various study and analysis categories used for such analyses, including the advantages and limitations of such techniques.

Indexed as

Genetic Predisposition to DiseaseCase-Control StudiesFemaleGenetic Association StudiesHistocompatibility TestingHLA AntigensHumansImmunogeneticsMalePedigreePolymorphism, GeneticReceptors, KIRHLA AntigensReceptors, KIR

Identifiers

PMID22665238
PMCPMC4209949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.