Evidence map›Paper›PMID 22665144›Full record

Trial reportNeurology2012

Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial.

V W Henderson, J A St John, H N Hodis, N Kono, C A McCleary, A A Franke, W J Mack, WISH Research Group

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00118846 (Phytoestrogens and Progression of Atherosclerosis), which is not on this map. Cited by 52 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 8 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00118846 phase2completednot on this map

Phytoestrogens and Progression of Atherosclerosis

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2004 to 2009Enrolled350ConditionsAtherosclerosisArms25 gm soy protein supplement, Placebo
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 8 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. The effects ofFrontiers in nutrition · 2025
    Pooled it
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  5. Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022
    Pooled it
  6. Pooled it
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  8. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2015
    Pooled it
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  12. Semantic Memory in the Clinical Progression of Alzheimer Disease.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2017
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

V W HendersonDepartments of Health Research and Policy (Epidemiology) and Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
J A St John
H N Hodis
N Kono
C A McCleary
A A Franke
W J Mack
WISH Research Group
University of Southern California · US

Funding

Phytoestrogens/Progression of Atherosclerosis SUPPLEMENTU01AT001653 · NCCIH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HODIS, HOWARD NEIL · 2003 to 2008
$9.2M
NCCIH NIH HHS U01-AT001653
6 · The paper itself

Abstract

objectiveTo determine the cognitive effects of long-term dietary soy isoflavones in a daily dose comparable to that of traditional Asian diets.

methodsIn the double-blind Women's Isoflavone Soy Health trial, healthy postmenopausal women were randomly allocated to receive daily 25 g of isoflavone-rich soy protein (91 mg of aglycone weight of isoflavones: 52 mg of genistein, 36 mg of daidzein, and 3 mg glycitein) or milk protein-matched placebo. The primary cognitive endpoint compared between groups at 2.5 years was change from baseline on global cognition, a composite of the weighted sum of 14 neuropsychological test score changes. Secondary outcomes compared changes in cognitive factors and individual tests.

resultsA total of 350 healthy postmenopausal women aged 45-92 years enrolled in this trial; 313 women with baseline and endpoint cognitive test data were included in intention-to-treat analyses. Adherence in both groups was nearly 90%. There was no significant between-group difference on change from baseline in global cognition (mean standardized improvement of 0.42 in the isoflavone group and 0.31 in the placebo group; mean standardized difference 0.11, 95% confidence interval [CI] -0.13 to 0.35). Secondary analyses indicated greater improvement on a visual memory factor in the isoflavone group (mean standardized difference 0.33, 95% CI 0.06-0.60) but no significant between-group differences on 3 other cognitive factors or individual test scores, and no significant difference within a subgroup of younger postmenopausal women.

conclusionFor healthy postmenopausal women, long-term dietary soy isoflavone supplementation in a dose comparable to that of traditional Asian diets has no effect on global cognition but may improve visual memory. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that long-term dietary supplementation with isoflavone-rich soy protein does not improve global cognition of healthy postmenopausal women.

Indexed as

Dietary SupplementsWomen's HealthAgedAged, 80 and overCognitionDouble-Blind MethodFemaleHumansIsoflavonesMemoryMiddle AgedPostmenopauseSoybean ProteinsTime FactorsIsoflavonesSoybean Proteins

Identifiers

PMID22665144
PMCPMC3369523
OpenAlexW1990101982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.