ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2012
Hypothalamic expression of snoRNA Snord116 is consistent with a link to the hyperphagia and obesity symptoms of Prader-Willi syndrome.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- A proof-of-concept study of pitolisant for excessive daytime sleepiness in patients with Prader-Willi syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Trial
- Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.World journal of pediatrics : WJP · 2025Article
- The emerging role of snoRNAs in human disease.Genes & diseases · 2023Review
- Next Steps in Prader-Willi Syndrome Research: On the Relationship between Genotype and Phenotype.International journal of molecular sciences · 2022Review
- Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims.Scientific reports · 2021Article
- A Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research.International journal of molecular sciences · 2021Review
- Epigenetics in Prader-Willi Syndrome.Frontiers in genetics · 2021Review
- Functional diversity of small nucleolar RNAs.Nucleic acids research · 2020Article
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- Caralluma fimbriata extract activity involves the 5-HT2c receptor in PWS Snord116 deletion mouse model.Brain and behavior · 2018Article
- Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.The Journal of clinical investigation · 2018Article
- Adult-onset deletion of the Prader-Willi syndrome susceptibility geneTranslational pediatrics · 2017Article
- Prader-Willi syndrome and atypical submicroscopic 15q11-q13 deletions with or without imprinting defects.European journal of medical genetics · 2016Article
- Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Scientific reports · 2016Article
- Snord116 is critical in the regulation of food intake and body weight.Scientific reports · 2016Article
- Article
- Highly restricted deletion of the SNORD116 region is implicated in Prader-Willi Syndrome.European journal of human genetics : EJHG · 2015Article
- Imprinting genes associated with endometriosis.EXCLI journal · 2014Review
- Apo-Ghrelin Receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain.Frontiers in endocrinology · 2014Review
- Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.Genes, brain, and behavior · 2013Article
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4 authors at 2 institutions in 1 country.
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Abstract
The hypothalamus is integral to the regulation of body homeostasis, including food intake, energy balance, and blood pressure. Dysfunction of the hypothalamus has been associated with a broad range of disorders; many of which are sex-dependent in prevalence. Small nucleolar (sno) RNAs are a group of small RNAs located in nucleoli that modulate chemical modifications and maturation of ribosomal or other RNAs. Recent data suggest that snoRNA Snord116 is important for the pathogenesis of Prader-Willi syndrome (PWS) characterized by hyperphagia and obesity. The current study was conducted to assess a potential cellular link between Snord116 and phenotypes of PWS. Data from mice revealed Snord116 expression in the medial hypothalamus, particularly within nuclei that are part of feeding circuitry. High expression of Snord116 was evident in the paraventricular (PVN) and ventromedial (VMH) nuclei, but particularly prevalent in the arcuate nucleus (ARC) according to in situ hybridization. Snord116 expression level in ventral hypothalamic dissections including ARC was significantly greater (by 2-fold) than that in cortex; and its expression level in dorsal hypothalamic dissections including PVN was double that in cortex. The enhanced expression pattern of Snord116 in hypothalamic nuclei was observed at weaning and young adult stages, but less obvious neonatally when expression was significantly more widespread. Therefore the expression of Snord116 likely is regulated developmentally. These results provide a new lead for understanding the mechanism(s) related to hyperphagia and obesity symptoms in PWS patients.
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